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Radiation Therapy or Combination Chemotherapy in Treating Young Patients With Hodgkin's Lymphoma

Information source: National Cancer Institute (NCI)
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Lymphoma

Intervention: bleomycin sulfate (Biological); chlorambucil (Drug); dacarbazine (Drug); doxorubicin hydrochloride (Drug); prednisolone (Drug); procarbazine hydrochloride (Drug); vinblastine sulfate (Drug); vincristine sulfate (Drug); radiation therapy (Radiation)

Phase: N/A

Status: Active, not recruiting

Sponsored by: Children's Cancer and Leukaemia Group

Official(s) and/or principal investigator(s):
Ann Barrett, Study Chair, Affiliation: University of Glasgow
Judith E. Kingston, MD, Affiliation: St. Bartholomew's Hospital
John Martin, MD, Affiliation: Royal Liverpool Children's Hospital, Alder Hey


RATIONALE: Radiation therapy uses high-energy x-rays to kill cancer cells. Drugs used in chemotherapy work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) may kill more cancer cells. PURPOSE: This clinical trial is studying how well radiation therapy or combination chemotherapy work in treating young patients with Hodgkin's lymphoma.

Clinical Details

Official title: Hodgkin's Disease Study

Study design: Masking: Open Label, Primary Purpose: Treatment

Detailed description: OBJECTIVES:

- Maintain the present satisfactory results of patients treated on protocol

UKCCSG-HD-8201 in pediatric patients with stage I-III Hodgkin's lymphoma treated with radiotherapy or combination chemotherapy comprising chlorambucil, procarbazine hydrochloride, prednisolone, vinblastine followed by doxorubicin hydrochloride, bleomycin, vincristine, and dacarbazine.

- Determine, by comparison with UKCCSG-HD-8201, if mediastinal irradiation can be safely

omitted from the management of pediatric patients with Hodgkin's lymphoma and bulky mediastinal disease.

- Determine if gallium scanning of the mediastinum after chemotherapy will identify

patients with residual active mediastinal disease.

- Improve disease control in patients with stage IV Hodgkin's lymphoma and slow

responders by intensifying treatment to patients who fail to achieve complete remission after 4 courses of chlorambucil, vinblastine, procarbazine hydrochloride, and prednisone. OUTLINE: This is a multicenter study. Patients are stratified according to stage of disease (I vs II-IV).

- Stage I: Patients undergo involved-field radiotherapy.

- Stage II-IV:

- CHLVPP chemotherapy: Patients receive CHLVPP chemotherapy comprising oral

chlorambucil, oral procarbazine hydrochloride, and oral prednisolone on days 1-14 and vinblastine IV on days 1-8. Treatment repeats every 28 days for 2 courses. Patients achieving complete resolution (CR) of measurable disease receive an additional 4 courses of CHLVPP. Patients with no response or progressive disease proceed to ABVD chemotherapy. Patients with shrinkage of measurable disease to < 50% original dimensions (GPR) receive 2 additional courses of CHLVPP. Patients achieving CR or GPR after completion of 2 additional courses of CHLVPP receive 4 more courses of CHLVPP. Patients achieving shrinkage of measurable disease to ≥ 50% of original dimension (PR) after 2 additional courses of CHLVPP OR patients not achieving CR after a total of 8 courses of CHLVPP proceed to ABVD chemotherapy.

- ABVD chemotherapy: Patients receive ABVD chemotherapy comprising doxorubicin

hydrochloride IV over 4 hours and bleomycin IV, vincristine IV, and dacarbazine IV on days 1 and 15. Treatment repeats every 28 days for 4-6 courses in the absence of disease progression or unacceptable toxicity.

- Mediastinal mass: Patients receive chemotherapy as per stages II-IV. Patients

presenting with airway or superior vena cava obstruction may also undergo radiotherapy. Patients achieving CR after completion of chemotherapy receive no further treatment. Patients achieving GPR or PR after completion of chemotherapy undergo gallium scan and CT scan of thorax with or without biopsy at the investigator's discretion. After completion of study treatment, patients are followed periodically. PROJECTED ACCRUAL: A total of 353 patients were accrued for this study.


Minimum age: N/A. Maximum age: N/A. Gender(s): Both.



- Histologically confirmed childhood Hodgkin's lymphoma by lymph node biopsy

- Any stage disease

- Patients with bilateral upper cervical disease with no evidence of

supraclavicular, thoracic inlet, or Waldeyers ring involvement are treated as having stage I disease PATIENT CHARACTERISTICS:

- Platelet count > 100,000/mm^3

- Absolute neutrophil count > 1,000/mm^3


- Not specified

Locations and Contacts

Additional Information

Clinical trial summary from the National Cancer Institute's PDQ® database

Last updated: August 1, 2013

Page last updated: August 23, 2015

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