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A Phase 2 Open Label Partially Randomized Trial to Evaluate the Efficacy, Safety and Tolerability of Combinations of Bedaquiline, Moxifloxacin, PA-824 and Pyrazinamide in Adult Subjects With Drug-Sensitive or Multi Drug-Resistant Pulmonary Tuberculosis.

Information source: Global Alliance for TB Drug Development
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Tuberculosis

Intervention: Pa-824 (Drug); bedaquiline (Drug); moxifloxacin (Drug); pyraziminide (Drug); isoniazid, rifampicin, pyrazinamide and ethambutol combination tablet (Drug)

Phase: Phase 2

Status: Recruiting

Sponsored by: Global Alliance for TB Drug Development

Official(s) and/or principal investigator(s):
Rodney Dawson, Principal Investigator, Affiliation: University of Cape Town Lung Institute

Overall contact:
Almari Conradie, Phone: 27 87 700 3900, Email: almari.conradie@tballiance.org

Summary

The purpose of this study is to determine the mycobactericidal activity of combinations of bedaquiline (J), moxifloxacin (M), PA-824 (Pa) and pyrazinamide (Z) regimens during 8 weeks of treatment.

Clinical Details

Official title: A Phase 2 Open-Label Partially Randomized Trial to Evaluate the Efficacy, Safety and Tolerability of Combinations of Bedaquiline, Moxifloxacin, PA-824 and Pyrazinamide During 8 Weeks of Treatment in Adult Subjects With Newly Diagnosed Drug-Sensitive or Multi Drug-Resistant, Smear-Positive Pulmonary Tuberculosis.

Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Primary outcome: The Bactericidal Activity as determined by the rate of change in time to sputum culture positivity, Days 0 - 56.

Secondary outcome:

The Bactericidal Activity as determined by the rate of change in time to sputum culture positivity, Days 0 - 2.

The Bactericidal Activity as determined by the rate of change in time to sputum culture positivity, Days 14 - 56.

The Bactericidal Activity as determined by the rate of change in colony forming units, Days 0 - 56.

The Bactericidal Activity as determined by the rate of change in colony forming units, Days 0 - 2.

The Bactericidal Activity as determined by the rate of change in colony forming units, Days 14 - 56.

Time to sputum culture conversion using data from solid media, Days 0 - 56.

Time to sputum culture conversion using data from liquid media, Days 0 - 56.

Pharmacokinetic analysis of Ctrough of Investigational Medicinal Products, Days 0 - 70.

Detailed description: The trial design is a phase 2, multi-center, open-label, partially randomized clinical trial in four parallel treatment groups. Subjects with drug-sensitive tuberculosis (DS-TB) will be randomized to receive either J(loading dose/three times a week)PaZ; or J(200mg)PaZ; or HRZE. Subjects with multi drug-resistant tuberculosis will receive J(200mg)MPaZ. The HRZE treatment arm is included as a control for the drug-sensitive treatments and as a control for the quantitative laboratory mycobacteriology testing. A total of approximately 240 male and female, newly diagnosed subjects with drug-sensitive or multi drug-resistant, smear positive pulmonary tuberculosis aged 18 to 75 years (inclusive) will be included in the study. A total of 180 subjects with drug-sensitive tuberculosis (60 per treatment arm) will be randomized. Up to 60 subjects with multi-drug resistant tuberculosis will be assigned. All subjects will have up to a maximum of 9 days screening, receive 8 weeks of treatment, and have follow-up visits at 2 and 12 weeks after study treatment completion or last dose of investigational medicinal product in the case of early withdrawal. Subjects who withdraw from the study after receiving < 14 days of investigational medicinal product, will only attend a follow-up visit at 2 weeks after last dose of investigational medicinal product. Upon treatment completion, the subjects with drug-sensitive tuberculosis will be provided with sufficient doses of standard of care tuberculosis treatment, as appropriate, to cover the time period from attending their last visit at the study clinic until their scheduled visit at the TB clinic. All subjects with drug sensitive and multi-drug resistant tuberculosis will be referred to the local community tuberculosis clinics for standard anti-tuberculosis chemotherapy according to National Tuberculosis Guidelines.

Eligibility

Minimum age: 18 Years. Maximum age: 75 Years. Gender(s): Both.

Criteria:

Inclusion Criteria: 1. Provide written, informed consent prior to all trial-related procedures. Male or female, aged between 18 and 75 years inclusive. 2. Body weight (in light clothing and with no shoes) between 35 and 100 kg, inclusive. 3. Tested at the trial appointed laboratory: M. Tb positive on molecular test (e. g. GeneXpert or Hain) and sputum smear-positive pulmonary TB on direct microscopy for acid-fast bacilli (at least 1+ on the IUATLD/WHO scale.

- For DS-TB treatment arms (defined as sensitive to rifampicin based on molecular

sensitivity testing), Subjects should be: 1. either newly diagnosed or untreated for at least 3 years after cure from a previous episode (Subject can give a history of cure and previous treatment); AND 2. Previous TB treatment must be discontinued as per exclusion criteria 16.

- For MDR-TB treatment arm (defined as resistant to rifampicin based on molecular

sensitivity testing), Subjects should be: 1. sensitive to moxifloxacin by molecular sensitivity testing; AND 2. either newly diagnosed or could have previously been treated for DS-TB and/or MDR-TB (< 7 days of treatment). Previous MDR-TB treatment must be discontinued as per exclusion criteria 17. 4. A chest X-ray picture which in the opinion of the Investigator is compatible with TB. 5. Ability to produce an adequate volume of sputum as estimated from a screening Coached Spot Sputum Sample assessment (estimated 10 ml or more overnight production). 6. Be of non-childbearing potential or using effective methods of birth control, as defined below: Non-childbearing potential:

1. Subject - not heterosexually active or practices sexual abstinence; or

2. Female Subject/sexual partner - bilateral oophorectomy, bilateral tubal ligation

and/or hysterectomy or has been postmenopausal with a history of no menses for at least 12 consecutive months; or

3. Male Subject/sexual partner - vasectomised or has had a bilateral orchidectomy

minimally three months prior to screening. Effective birth control methods: A double contraceptive method should be used as follows: 1. Double barrier method which can include any 2 of the following: a male condom, diaphragm, cervical cap, or female condom (male and female condoms should not be used together); or 2. Barrier method (one of the above) combined with hormone-based contraceptives or an intra-uterine device for the female Subject/partner; and are willing to continue practicing birth control methods throughout treatment and for 6 months (both male and female Subjects) after the last dose of study medication or discontinuation from study medication in case of premature discontinuation. (Note: Hormone-based contraception alone may not be reliable when taking IMP; therefore, hormone-based contraceptives alone cannot be used by female Subjects or female partners of male Subjects to prevent pregnancy). Exclusion Criteria: Medical Criteria 1. Evidence of clinically significant (as judged by the Investigator), metabolic, gastrointestinal, cardiovascular, musculoskeletal, ophthalmological, pulmonary, neurological, psychiatric or endocrine diseases, malignancy, or other abnormalities (other than the indication being studied) including malaria. A rapid test for malaria may be carried out if indicated. 2. Karnofsky performance status score of < 60%. 3. Poor general condition where any delay in treatment cannot be tolerated per discretion of the Investigator. 4. Clinically significant evidence of extrathoracic TB (e. g. miliary TB, abdominal TB, urogenital TB, osteoarthritic TB, TB meningitis), as judged by the Investigator. 5. History of allergy or hypersensitivity to any of the study Investigational Medicinal Products or related substances. 6. Known or suspected current alcohol and/or drug abuse (positive urine drug screen) or history thereof within the past 2 years that is, in the opinion of the Investigator, sufficient to compromise the safety and/or cooperation of the Subject. 7. For HIV infected Subjects: 1. having a CD4+ count <100 cells/µL; 2. with an AIDS-defining opportunistic infection or malignancies (except pulmonary TB); 3. currently treated with or will need to initiate antiretroviral therapy (ART) which is not compatible with the allowed ARTs and is not considered an appropriate candidate for switching to a regimen of ARVs which is allowed as follows:

- Triple nucleoside reverse transcriptase inhibitor (NRTI) based regimen

consisting of zidovudine, lamivudine, and abacavir;

- Nevirapine based regimen consisting of nevirapine in combination with any

NRTIs;

- Lopinavir/ritonavir (Aluvia™) based regimen consisting of

lopinavir/ritonavir (Aluvia™) in combination with any NRTIs;

- Raltegravir in combination with nucleoside reverse transcriptase inhibitors

(NRTIs); 4. cannot ensure a 2 week interval between commencing IMP and the start of ART. 8. Having participated in other clinical study/ies with investigational agent/s within 8 weeks prior to trial start. 9. Significant cardiac arrhythmia requiring medication. 10. Subjects with the following at screening (per measurements and reading done by Central ECG): 1. Marked prolongation of QT/QTc interval, e. g. confirmed demonstration of QTcF (Fridericia correction) or QTcB (Bazett correction) interval >450 ms at screening; 2. History of additional risk factors for Torsade de Pointes, e. g. heart failure, hypokalemia, family history of Long QT Syndrome; 3. Use of concomitant medications that are known to prolong the QT/QTc interval (see exclusion criteria 19); 4. Any clinically significant, in the opinion of the Investigator, ECG abnormality. 11. Females who are pregnant, breast-feeding, or planning to conceive a child during the study or within 6 months of cessation of treatment. Males planning to conceive a child during the study or within 6 months of cessation of treatment. 12. Diabetes Mellitus resulting in hospitalization in the past year. 13. Evidence of lens opacity on slit lamp ophthalmologic examination as defined by a grading of >1+ on the AREDS2 grading system. 14. For males, any history of a clinically significant abnormality in the reproductive system. Specific Treatments 15. Previously received treatment with PA-824, bedaquiline or moxifloxacin as part of a clinical trial. 16. For the DS-TB treatment arms: treatment with any drug active against M. Tb within the 3 years prior to Day 1 (including but not limited to isoniazid, ethambutol, amikacin, bedaquiline, clofazimine, cycloserine, fluoroquinolones, rifabutin, rifampicin, streptomycin, kanamycin, para-aminosalicylic acid, rifapentine, pyrazinamide, thioacetazone, capreomycin, thioamides, metronidazole). Exceptions include the use of fluoroquinolones and metronidazole as short-term treatment (≤2 weeks) for Non-M. Tb infections. Treatment should have been discontinued at least 3 months prior to Day 1. Subjects who have previously received isoniazid prophylactically may be included in the trial as long as that treatment is/was discontinued at least 7 days prior to randomization into this trial. 17. MDR-TB Subjects may have previously been treated for DS-TB with first-line TB drugs (isoniazid, rifampicin, ethambutol, pyrazinamide and/or streptomycin) and/or received ≤7 days MDR-TB treatment, provided that treatment is/was discontinued at least 7 days prior to randomization. It should be confirmed that the MDR-TB treatment can be safely stopped and the screening period is long enough to allow for a washout period of 5 times the longest half-life of the drugs. 18. Any diseases or conditions in which the use of the standard TB drugs or any of their components is contra-indicated, including but not limited to acute gout, allergy to any TB drug, their component or to the IMP. 19. Use of any drug within 30 days prior to dosing known to prolong QTc interval (including but not limited to amiodarone, bepridil, chloroquine, chlorpromazine, cisapride, cyclobenzaprine, clarithromycin, disopyramide dofetilide, domperidone, droperidol, erythromycin, halofantrine, haloperidol, ibutilide, levomethadyl, mesoridazine, methadone, pentamidine, pimozide, procainamide, quinidine, sotalol, sparfloxacin, thioridazine). Exceptions may be made for Subjects that have received 3 days or less of one of these drugs or substances, if there has been a wash-out period before administration of IMP equivalent to at least 5 half-lives of that drug or substance. Subjects who have taken drugs with long elimination half-lives such as amiodarone should be discussed with the Sponsor. 20. Use of any drugs or substances within 30 days prior to dosing known to be strong inhibitors or inducers of cytochrome P450 enzymes (including but not limited to quinidine, tyramine, ketoconazole, fluconazole, testosterone, quinine, gestodene, metyrapone, phenelzine, doxorubicin, troleandomycin, cyclobenzaprine, erythromycin, cocaine, furafylline, cimetidine, dextromethorphan). Exceptions may be made for Subjects that have received 3 days or less of one of these drugs or substances, if there has been a wash-out period before administration of IMP equivalent to at least 5 half-lives of that drug or substance. 21. Any ARVs other than allowable ARVs detailed in exclusion criteria no. 7 above. Based on Laboratory Abnormalities: 22. Subjects with the following toxicities at screening as defined by the enhanced Division of Microbiology and Infectious Disease (DMID) adult toxicity table: 1. serum magnesium and calcium (corrected for albumin) levels outside of the laboratory's reference range 2. lipase grade 3 or greater (>2. 0 x ULN); 3. creatinine grade 2 or greater (>1. 5 x ULN); 4. hemoglobin grade 4 (<6. 5 g/dL); 5. platelets > grade 2 (under 50x10(9) cells/L); 6. serum potassium less than the lower limit of normal for the laboratory; 7. aspartate aminotransferase (AST) grade 3 or greater (≥3. 0 x ULN) to be excluded; 8. alanine aminotransferase (ALT) grade 3 or greater (≥3. 0 x ULN) to be excluded;

9. alkaline phosphatase (ALP) grade 4 (>8. 0 x ULN) to be excluded, grade 3 (≥3. 0 -

8. 0 x ULN) must be discussed with and approved by the Sponsor Medical Monitor; 10. total bilirubin grade 3 or greater (≥2. 0 x ULN, or ≥1. 50 x ULN when accompanied by any increase in other liver function test) to be excluded, grade 2 (≥1. 50 x ULN, or ≥1. 25 x ULN when accompanied by any increase in other liver function test) must be discussed with and approved by the Sponsor Medical Monitor

Locations and Contacts

Almari Conradie, Phone: 27 87 700 3900, Email: almari.conradie@tballiance.org

TASK Applied Science, Cape Town 7531, South Africa; Recruiting
Andreas Diacon, Phone: 27(0) 21 949 7751, Email: ahd@sun.ac.za
Andreas Diacon, Principal Investigator

University of Cape Town Lung Institute (Pty) Ltd, Cape Town 7937, South Africa; Recruiting
Rodney Dawson, Phone: 27(0) 21 406 6864, Email: rodney.dawson@uct.ac.za
Rodney Dawson, Principal Investigator

THINK: Tuberculosis & HIV Investigative Network of KwaZulu-Natal, Durban, South Africa; Recruiting
Suzanne Staples, Phone: 27(0)31 303 1120, Email: s.staples@thinksa.org.za
Suzanne Staples, Principal Investigator

CHRU Themba Lethu Clinic, Johannesburg, South Africa; Recruiting
Mohammed Siddique Rassool, Phone: 27(0) 11 276 8813, Email: mrassool@witshealth.co.za
Mohammed Siddique Rassool, Principal Investigator

University of Witwatersrand, Clinical HIV Research Unit (CHRU), Helen Joseph Hospital, Johannesburg, South Africa; Recruiting
Francesca Conradie, Phone: 27(0) 11 531 4347, Email: fconradie@witshealth.co.za
Francesca Conradie, Principal Investigator

Ifakara Health Institute, Bagamoyo, Tanzania; Recruiting
Frederick Haraka, Phone: 255 23 244 0293, Email: fharaka@ihi.or.tz
Frederick Haraka, Principal Investigator

NIMR-Mbeya Medical Research Centre (MMRC), Mbeya, Tanzania; Recruiting
Nyanda Elias, Phone: 255 25 250 3364, Email: nelias@nimr-mmrc.org
Nyanda Elias, Principal Investigator

Uganda Case Western Reserve University Research Collaboration, Kampala, Uganda; Recruiting
Alphonse Okwera, Phone: 256 752 437 675, Email: a_okwera@mucwru.or.ug
Alphonse Okwera, Principal Investigator

The Aurum Institute: Tembisa Hospital, Tembisa, Gauteng 1632, South Africa; Recruiting
Uthestra Chetty, Phone: 27(0) 10 590 1319, Email: uchetty@auruminstitute.org
Uthestra Chetty, Principal Investigator

Klerksdorp Tshepong Hospital, Jouberton, Klerksdorp 2570, South Africa; Recruiting
Ebrahim Variava, Phone: 27(0)18 406 3111, Email: variava@worldonline.co.za
Ebrahim Variava, Principal Investigator

Additional Information

Starting date: November 2014
Last updated: May 7, 2015

Page last updated: August 23, 2015

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