Effect of Gabapentin on Idiopathic Subjective Tinnitus
Information source: Islamic Azad University of Mashhad
Information obtained from ClinicalTrials.gov on June 20, 2008
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Subjective Tinnitus
Intervention: Gabapentin (Drug); placebo (Other)
Phase: Phase 2
Status: Active, not recruiting
Sponsored by: Islamic Azad University of Mashhad Official(s) and/or principal investigator(s):
Mahboobeh Adami Dehkordi, MD, Principal Investigator, Affiliation: ENT department of Mashhad azad university of mashhad
Summary
The purpose of this study is to determine wether Gabapentin which is useful for treating
neuropathic pains, is effective on idiopathic subjective tinnitus.
Clinical Details
Official title: Phase 2 Effect of Gabapentin on Idiopathic Subjective Tinnitus
Study design: Treatment, Randomized, Double Blind (Subject, Investigator), Placebo Control, Parallel Assignment, Efficacy Study
Primary outcome: Reduction in the sensation of Tinnitus by the patient or complete resolution of tinnitus;by thre patient's scoring it from one to ten, before and after prescribing Gabapentin.
Secondary outcome: Relieve of complications of tinnitus, such as sleep difficulties.
Detailed description:
Tinnitus is the perception of sound in the absence of acoustic stimulation. It can be
subjective or objective. .
Despite numerous researches,no effective treatment for people who suffer from tinnitus has
yet been stablished.
As there are many evidences suggesting that loss of inhibition in the central nervous system
may be responsible for many aspects of auditory dysfunction,including tinnitus; and as
Gabapentin (Neurontin), a gama-aminobutyric acid (GABA) analogue, is an effective medication
in conditions where inhibition in the CNS is impaired; we guess that Gabapentin might be
useful for treating idiopathic subjective tinnitus.
Eligibility
Minimum age: 18 Years.
Maximum age: 75 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- patients with subjective idiopathic tinnitus
Exclusion Criteria:
- tinnitus with known underlying cause
- pregnant women and patients younger than 18 or older than 75 years
- patients with impaired renal function
Locations and Contacts
ENT department of Mashhad Azad medical university, Mashhad, Khorasan razavi 91786 56553, Iran, Islamic Republic of
Additional Information
Starting date: January 2007
Ending date: April 2008
Last updated: November 26, 2007
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