Lamictal in the Treatment of Post-Herpetic Neuralgia
Information source: George Washington University
Information obtained from ClinicalTrials.gov on November 03, 2008
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Neuralgia, Postherpetic
Intervention: Lamictal in the treatment of Post-Herpetic Neuralgia (Drug)
Phase: Phase 2/Phase 3
Status: Recruiting
Sponsored by: George Washington University Official(s) and/or principal investigator(s):
Perry K. Richardson, M.D., Principal Investigator, Affiliation: The George Washington University Medical Faculty Associates
Overall contact:
Elizabeth Kingery, RN, Phone: 202-741-2729, Email: ekingery@mfa.gwu.edu
Summary
To assess the efficacy of Lamictal for the treatment of pain and reduction of allodynia in
patients with post herpetic neuralgia.
Clinical Details
Official title: Lamictal in the Treatment of Post-Herpetic Neuralgia-A Safety, Efficacy,Randomized, Double Blind, Placebo Controlled, Cross-Over Study
Study design: Randomized, Double-Blind, Placebo Control, Crossover Assignment
Eligibility
Minimum age: 18 Years.
Maximum age: 85 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- All patients will be over the age of 18,
- Need to have a diagnosis of Post-Herpetic Neuralgia,
- Minimum of 4 on the Likert Pain Scale,
- If currently taking TCA and/or Gabapentin, need to have been on stable dose for
minimum of 4 weeks
Exclusion Criteria:
- Currently on any antiepileptic drugs (AED), except for Gabapentin.
- Currently taking opioid or unwilling to washout prior to the study,
- Pregnant and lactating,
- Have active severe systemic disease,
- History of Stevens-Johnson syndrome or TEN,
- Clinically significant abnormal lab values,
- Known drug allergy to Lamictal,
- Patients on Fibrates (Tricor and Lopid),
- History of major psychiatric disturbance and substance abuse.
- Valproate due to increase chances of severe rash,
- Lidocaine Patch,
- Use of hormonal contraceptives (birth control pills, patch, ring, injection)
Locations and Contacts
Elizabeth Kingery, RN, Phone: 202-741-2729, Email: ekingery@mfa.gwu.edu
Medical Faculty Associates, Washington, DC, District of Columbia 20037, United States; Recruiting
Elizabeth Kingery, RN, Phone: 202-741-2729, Email: ekingery@mfa.gwu.edu
Additional Information
Last updated: February 22, 2006
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