Study of Medication and Placebo Response in Major Depression
Information source: University of California, Los Angeles
Information obtained from ClinicalTrials.gov on March 24, 2008
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Depressive Disorder, Major
Intervention: sertraline (Zoloft) (Drug)
Phase: Phase 4
Status: Completed
Sponsored by: University of California, Los Angeles Official(s) and/or principal investigator(s):
Andrew F. Leuchter, M.D., Principal Investigator, Affiliation: University of California, Los Angeles
Summary
The primary purpose of the research study is to use recordings of brain electrical activity
(through electroencephalogram, or EEG) and symptom measurements to determine whether patients
are likely to show a response to medication or placebo treatment during a treatment trial for
depression.
Clinical Details
Study design: Treatment, Randomized, Double-Blind, Placebo Control, Crossover Assignment, Efficacy Study
Primary outcome: depressive symptoms
Secondary outcome: brain electrical activity (EEG)
Eligibility
Minimum age: 18 Years.
Maximum age: 65 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- Clinical Diagnosis of Unipolar Major Depression
Exclusion Criteria:
- Substance Abuse, Psychotic Disorder, History of Severe Head Trauma
Locations and Contacts
UCLA Neuropsychiatric Institute & Hospital, Los Angeles, California 90024, United States
Additional Information
Depression Research at UCLA - Click here for more information about this study: Study of Medication and Placebo Response in Major Depression
Related publications: Leuchter AF, Cook IA, Witte EA, Morgan M, Abrams M. Changes in brain function of depressed subjects during treatment with placebo. Am J Psychiatry. 2002 Jan;159(1):122-9. Cook IA, Leuchter AF, Morgan M, Witte E, Stubbeman WF, Abrams M, Rosenberg S, Uijtdehaage SH. Early changes in prefrontal activity characterize clinical responders to antidepressants. Neuropsychopharmacology. 2002 Jul;27(1):120-31. Leuchter AF, Morgan M, Cook IA, Dunkin J, Abrams M, Witte E. Pretreatment neurophysiological and clinical characteristics of placebo responders in treatment trials for major depression. Psychopharmacology (Berl). 2004 Dec;177(1-2):15-22. Epub 2004 Jul 14.
Starting date: December 2003
Ending date: March 2006
Last updated: April 20, 2007
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