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Hydralazine Versus Labetalol for the Management of Hypertensive Disorders of Pregnancy

Information source: Saint Thomas Hospital, Panama
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Hypertension, Pregnancy Induced

Intervention: Hydralazine (Drug); Labetalol (Drug)

Phase: Phase 3

Status: Completed

Sponsored by: Saint Thomas Hospital, Panama


Hypertensive crisis (defined as a systolic pressure > 160mmHg or a diastolic pressure > 110mmHg) in patients with a hypertensive disorder of pregnancy is a serious complication with severe and even deadly consequences. The management in this population had been studied, but no consensus has been reached with regards to which treatment is better. Our study will compare two drugs: Hydralazine and Labetalol for the management of hypertensive crisis.

Clinical Details

Official title: Hydralazine vs. Labetalol for the Management of Hypertensive Crisis in Patients With Hypertensive Disorders of Pregnancy. A Randomized Controlled Trial.

Study design: Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Primary outcome: Control of Hypertensive Crisis

Secondary outcome:

Adverse reactions

Number of doses


Minimum age: N/A. Maximum age: N/A. Gender(s): Female.


Inclusion Criteria:

- Gestational age > 24 weeks.

- Hypertensive Crisis (systolic pressure > 160 mmHg / diastolic pressure < 110mmHg).

Exclusion Criteria:

- Known allergy to hydralazine.

- Known allergy to labetalol.

- Severe Bradycardia

Locations and Contacts

Saint Thomas Maternity Hospital, Panama, Panama
Additional Information

Starting date: July 2012
Last updated: May 16, 2013

Page last updated: August 23, 2015

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