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Study of Gleevec and Weekly Paclitaxel in Patients Aged 70 or Older With Advanced Non-small Cell Lung Cancer

Information source: New Mexico Cancer Care Alliance
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Non-small Cell Lung Cancer

Intervention: Imatinib mesylate (Drug); Paclitaxel (Drug)

Phase: Phase 2

Status: Completed

Sponsored by: New Mexico Cancer Care Alliance

Official(s) and/or principal investigator(s):
Julie Bauman, MD, Principal Investigator, Affiliation: University of New Mexico Cancer Center

Summary

This study will evaluate the clinical efficacy of combining Gleevec (imatinib mesylate), a PDGFR antagonist, with front-line, single-agent paclitaxel in a cohort of elderly patients with advanced, non-small cell lung cancer.

Clinical Details

Official title: A Phase II Study of Intermittent Gleevec® (Imatinib Mesylate) and Weekly Paclitaxel in Patients Aged 70 or Older With Advanced Non-small Cell Lung Cancer

Study design: Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Primary outcome: Response Rate

Secondary outcome:

Overall Survival

Progression Free Survival

Toxicities

Detailed description: Paclitaxel 90 mg/m2 IV on days 3, 10, 17 Imatinib 600 mg/day, oral administration in 4-day pulses bracketing each paclitaxel infusion (days 1-4; 8-11; 15-18) Cycle length: 28 days Number of cycles: up to 6

Eligibility

Minimum age: 70 Years. Maximum age: N/A. Gender(s): Both.

Criteria:

Inclusion Criteria:

- Age ≥ 70 years

- Histologic or cytologic diagnosis of non-small cell lung cancer

- At least one site of measurable disease, as defined by the modified RECIST criteria

(See section 7. 6)

- Stage IIIB with pleural effusion or Stage IV disease. Includes patients who received

surgery alone for early stage disease, now in relapse with advanced disease. Staging is according to the American Joint Committee on Cancer classification scheme, 6th edition. 48

- Adequate hepatic, renal and marrow function

- Liver function tests: total bilirubin < 1. 25 x upper limit of normal (ULN), AST

and ALT < 2. 5 x ULN, Creatinine < 1. 5 x ULN

- Baseline absolute neutrophil count > 1500/μL

- Baseline platelet count > 100,000/μL

- ECOG Performance Status 0, 1 or 2 at the time of informed consent. (See Appendix 1)

- Written, voluntary consent

- Patients with reproductive potential must use an acceptable contraceptive method.

Such methods include: 1) Male hormonal contraception; 2) Partner without reproductive potential, including post-menopausal status or history of tubal ligation; 3) Partner with intrauterine device (IUD) or contraceptive vaginal ring; 4) Partner takes oral contraceptive pill, wears contraceptive patch, or has contraceptive implant; 5) Routine use of barrier method, such as condoms or diaphragm, during sexual intercourse. Exclusion Criteria: Uncontrolled brain metastasis. Patients with known brain metastasis must have completed treatment with surgery, radiation or both. In addition, they must be off corticosteroids.

- Symptomatic neuropathy (Grade 2 or higher)

- Prior chemotherapy for advanced non-small cell lung cancer. (Prior adjuvant,

neoadjuvant, or chemoradiotherapy for NSCLC is permitted, provided at least 6 months elapsed prior to documented metastatic recurrence.)

- Patient is < 5 years free of another primary malignancy, except: a) if the other

malignancy is basal cell carcinoma or cervical carcinoma in situ or b) if the other primary malignancy is not considered clinically significant and is requiring no active intervention

- Prior radiation therapy to > 25% of bone marrow

- Grade III/IV congestive heart failure, as defined by NYHA criteria, or myocardial

infarction within 6 months.

- Any serious or uncontrolled concomitant disorder that, in the opinion of the

investigator, would compromise the patient's ability to complete the study.

- Patient has known chronic liver disease, e. g. diagnosis of chronic active hepatitis

or cirrhosis.

- Major surgery two weeks prior to study treatment

- Patient with any significant history of non-compliance to medical regimens or with

inability to grant reliable informed consent

- Any condition requiring continuous administration of systemic corticosteroids.

- The patient is on therapeutic anti-coagulation with warfarin.

Locations and Contacts

University of New Mexico Cancer Center, Albuquerque, New Mexico 87106, United States

University of New Mexico Cancer Center @ Lovelace Medical Center, Albuquerque, New Mexico 87102, United States

Univ. of Washington Fred Hutchinson Cancer Research Center (UW-FHCRC), Seattle, Washington 98109-1024, United States

Additional Information

Starting date: August 2009
Last updated: June 6, 2015

Page last updated: August 23, 2015

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