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Citalopram Versus Citalopram Plus Pindolol in Major Depressive Disorder

Information source: Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Major Depressive Disorder; Antidepressant Treatment Response

Intervention: Pindolol (Drug)

Phase: Phase 2

Status: Completed

Sponsored by: Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau

Official(s) and/or principal investigator(s):
Enric Álvarez, MD, PhD, Principal Investigator, Affiliation: Department of Psychiatry. Hospital de la Santa Creu i Sant Pau
Víctor Pérez, MD, PhD, Study Director, Affiliation: Department of Psychiatry. Hospital de la Santa Creu i Sant Pau
Francesc Artigas, PhD, Study Chair, Affiliation: Neurochemistry department. Consejo Superior de Investigaciones Científicas

Summary

The purpose of this study is to examine whether the speed of the clinical antidepressant action of citalopram can be accelerated by administering double doses of pindolol (15 mg/day, tid) which presumably should lead to increased 5-HT1A autoreceptor occupancy.

Clinical Details

Official title: Citalopram Versus Citalopram Plus Pindolol in Latency of Antidepressant Response Shortening in Major Depressive Disorder

Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Primary outcome: Scores on Hamilton Depression Rating Scale

Detailed description: Design, Settings, and Participants. A randomised, double-blind, placebo-controlled trial with MDD patients allocated to two treatment arms: citalopram + pindolol versus citalopram + placebo. Participants: outpatients with a depressive episode (DSM-IV criteria) were selected from a general hospital.

Eligibility

Minimum age: 18 Years. Maximum age: 65 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- Patients with a depressive episode

- HDRS score > 18

- Written informed consent

Exclusion Criteria:

- suicidal risk > 3

- severe organic illness

- other psychotropic drugs

Locations and Contacts

Outpatients Service of Psychiatry Department. Hospital de la Santa Creu i Sant Pau, Barcelona, Catalonia 08025, Spain
Additional Information

Starting date: December 2002
Last updated: July 1, 2009

Page last updated: August 23, 2015

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