Renal Function in Patients Submitted to Myocardial Revascularization Surgery
Information source: UPECLIN HC FM Botucatu Unesp
ClinicalTrials.gov processed this data on August 23, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Coronary Disease
Phase: N/A
Status: Terminated
Sponsored by: UPECLIN HC FM Botucatu Unesp Official(s) and/or principal investigator(s): Pedro TG Vianna, MD, Principal Investigator, Affiliation: Faculdade de Medicina de Botucatu UNESP
Summary
Acute renal insufficiency (ARI) represents a frequent and serious complication in patients
submitted to cardiac surgery, and is associated with increases in time of hospitalization,
costs, morbidity and mortality. Its incidence varies from 3. 5% to 31%. The present study
aims to evaluate renal function and oxidative stress in patients submitted to
revascularization surgery with extracorporeal circulation (ECC), comparing targeted venous
anesthesia controlled with propofol and inhalational anesthesia with isoflurane.
Clinical Details
Official title: Evaluation of Renal Function and Oxidative Stress in Patients Submitted to Myocardial Revascularization Surgery, With Extracorporeal Circulation, and Anesthesia With Isoflurane or Propofol
Study design: Observational Model: Case Control, Time Perspective: Prospective
Detailed description:
Acute renal insufficiency (ARI) represents a frequent and serious complication in patients
submitted to cardiac surgery, and is associated with increases in time of hospitalization,
costs, morbidity and mortality. Its incidence varies from 3. 5% to 31%. The present study
aims to evaluate renal function and oxidative stress in patients submitted to
revascularization surgery with ECC, comparing targeted venous anesthesia controlled with
propofol and inhalational anesthesia with isoflurane. The study will be conducted at the
Botucatu Medical School (FMB) and will analyze 60 patients, divided into two randomized
groups, submitted to revascularization surgery of the myocardium with ECC. The researcher
responsible for data collection from patients will not have knowledge of the type of
anesthesia being delivered to the patient. Blood samples will be collected by central venous
access for dosing of troponin I, troponin T, CKMB, MDA, creatinine, urea, albumin and
cystatin C. Renal function will be evaluated by serum cystatin C and creatinine and the
estimated glomerular filtration rate (GFR). GFR will be measured by means of serum cystatin
C (Larsson's formula) and by serum creatinine through the Cockcroft-Gault formula (CG) and
by the MDRD formula (Modification of Diet in Renal Disease).Markers of renal tubular
function will be dosed in the urine, including: alkaline phosphatase, γ -
glutamyltransferase(γ-GT), β 2 microglobulin, creatinine and urinary cystatin C.
Eligibility
Minimum age: 18 Years.
Maximum age: 75 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- both sexes,
- aged from 18 to 75 years,
- submitted to revascularization surgery of the myocardium
- extracorporeal circulation,
- who had consented to participation by signing the Terms of Free and Clear Consent.
Exclusion Criteria:
- history of hepatic or renal dysfunction,
- history involving acute myocardial infarct
- patients that made use of vitamin C and E;
- patients presenting other cardiac pathologies (valvular, congenital, corrected or not
in the same operational act).
Locations and Contacts
Faculdade de Medicina de Botucatu, Botucatu, Sao Paulo, Brazil
Upeclin, Botucatu, Sao Paulo, Brazil
Additional Information
Starting date: December 2008
Last updated: June 24, 2015
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