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Renal Function in Patients Submitted to Myocardial Revascularization Surgery

Information source: UPECLIN HC FM Botucatu Unesp
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Coronary Disease

Phase: N/A

Status: Terminated

Sponsored by: UPECLIN HC FM Botucatu Unesp

Official(s) and/or principal investigator(s):
Pedro TG Vianna, MD, Principal Investigator, Affiliation: Faculdade de Medicina de Botucatu UNESP

Summary

Acute renal insufficiency (ARI) represents a frequent and serious complication in patients submitted to cardiac surgery, and is associated with increases in time of hospitalization, costs, morbidity and mortality. Its incidence varies from 3. 5% to 31%. The present study aims to evaluate renal function and oxidative stress in patients submitted to revascularization surgery with extracorporeal circulation (ECC), comparing targeted venous anesthesia controlled with propofol and inhalational anesthesia with isoflurane.

Clinical Details

Official title: Evaluation of Renal Function and Oxidative Stress in Patients Submitted to Myocardial Revascularization Surgery, With Extracorporeal Circulation, and Anesthesia With Isoflurane or Propofol

Study design: Observational Model: Case Control, Time Perspective: Prospective

Detailed description: Acute renal insufficiency (ARI) represents a frequent and serious complication in patients submitted to cardiac surgery, and is associated with increases in time of hospitalization, costs, morbidity and mortality. Its incidence varies from 3. 5% to 31%. The present study aims to evaluate renal function and oxidative stress in patients submitted to revascularization surgery with ECC, comparing targeted venous anesthesia controlled with propofol and inhalational anesthesia with isoflurane. The study will be conducted at the Botucatu Medical School (FMB) and will analyze 60 patients, divided into two randomized groups, submitted to revascularization surgery of the myocardium with ECC. The researcher responsible for data collection from patients will not have knowledge of the type of anesthesia being delivered to the patient. Blood samples will be collected by central venous access for dosing of troponin I, troponin T, CKMB, MDA, creatinine, urea, albumin and cystatin C. Renal function will be evaluated by serum cystatin C and creatinine and the estimated glomerular filtration rate (GFR). GFR will be measured by means of serum cystatin C (Larsson's formula) and by serum creatinine through the Cockcroft-Gault formula (CG) and by the MDRD formula (Modification of Diet in Renal Disease).Markers of renal tubular

function will be dosed in the urine, including: alkaline phosphatase, γ -

glutamyltransferase(γ-GT), β 2 microglobulin, creatinine and urinary cystatin C.

Eligibility

Minimum age: 18 Years. Maximum age: 75 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- both sexes,

- aged from 18 to 75 years,

- submitted to revascularization surgery of the myocardium

- extracorporeal circulation,

- who had consented to participation by signing the Terms of Free and Clear Consent.

Exclusion Criteria:

- history of hepatic or renal dysfunction,

- history involving acute myocardial infarct

- patients that made use of vitamin C and E;

- patients presenting other cardiac pathologies (valvular, congenital, corrected or not

in the same operational act).

Locations and Contacts

Faculdade de Medicina de Botucatu, Botucatu, Sao Paulo, Brazil

Upeclin, Botucatu, Sao Paulo, Brazil

Additional Information

Starting date: December 2008
Last updated: June 24, 2015

Page last updated: August 23, 2015

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