Medical literature about awareness during general anesthesia is rare in China, and some small
sampled studies in China showed a significantly higher incidence (1. 5～6%) of intra-operative
awareness compared with western countries. We sponsored this multicenter, large sampled,
prospective study to determine the incidence of intra-operative awareness in China, and the
preservation effect of BIS monitor on the incidence of awareness.
Methods: This is a prospective, nonrandomized descriptive cohort study that was conducted at
25 academic medical centers in China. 11,197 patients (age＞12, intubation or LMA during
anesthesia) form 25 medical centers were enrolled to be interviewed by research stuff for
evaluation of awareness at the 1st and 4th day after their general anesthesia. The structured
interview questions were:⑴What is the last thing you remembered before you went to sleep?
⑵What is the first thing you remembered when you woke up? ⑶Can you remember anything between
these two periods? ⑷Did you dream during your operation? ⑸What was the worst thing about your
operation? An evaluation committee independent from the research stuff was constituted to
verify the data from the medical centers. And then the incidence of intra-operative awareness
in China was determined. General condition and details of the anesthesia procedure of the
patients were also recorded during the anesthesia for a binary logistic regression analysis.
Department of Anesthesiology, Beijing Hospital, Beijing 100730, China; Completed
Department of Anesthesiology, China-Japan Friendship Hospital, BEIJING 100029, China; Completed
Department of Anesthesiology, Beijing Command General Hospital, BEIJING 100700, China; Completed
Department of Anesthesiology, Beijing Obstetrics Gynecology Hospital, BEIJING 100006, China; Completed
Department of Anesthesiology, Beijing Hangtian General Hospital, BEIJING 100076, China; Completed
Departmet of Anesthesiology, Beijing Chao Yang Hospital, Capital Medical University, Beijing 100020, China; Recruiting
Liang Xu, M.D., Phone: +8613810317299, Email: leonnel@msn.com
Yun Yue, M.D., Phone: +861085231463, Email: yueyun@hotmail.com
Department of Anesthesioly,Peking University First Hospital, Beijing 100034, China; Completed
Department of Anesthesiology, Peking University Third Hospital, Beijing 100083, China; Completed
Department of Anesthesiology, Beijing Friendship Hospital, Beijing 100050, China; Completed
Department of Anesthesiology, Beijing Tongren Hospital, Beijing 100730, China; Completed
Department of Anesthesiology, Xuanwu Hospital Capital Medical University, Beijing 100053, China; Completed
Department of Anesthesiology, Shanghai Rui Jin Hospital, SHANGHAI 200025, China; Completed
Department of Anesthesiology, Shanghai Zhongshan Hospital, SHANGHAI 200032, China; Completed
Department of Anesthesiology, Shanghai Xinhua Hospital, SHANGHAI 200092, China; Completed
Department of Anesthesiology, Fuzhou General Hospital, FUZHOU, FUJIAN 354200, China; Completed
Department of Anesthesiology, Guangzhou first people ' s hospital, GUANGZHOU, GUANGDONG 510180, China; Completed
Department of Anesthesiology, Nanfang Hospital, GUANGZHOU, GUANGDONG 510515, China; Completed
Department of Anesthesiology, Wuhan Union Hospital, WUHAN, HUBEI 430022, China; Completed
Department of Anesthesiology, Xiangya Hospital of Central South University, CHANGSHA, HUNAN 410078, China; Completed
Department of Anesthesiology, the First Hospital of Jilin University, CHANGCHUN, JILIN 130021, China; Completed
Department of Anesthesiology, The First Hospital of China Medical University, SHENYANG, LIAONING 110001, China; Completed
Department of Anesthesiology, First Affiliated Hospital of Medical College of Xi'an Jiaotong University, XI'AN, SHANXI 710061, China; Completed
Department of Anesthesiology, Second Affiliated Hospital of Medical College of Xi'an Jiaotong University, XI'AN, SHANXI 710000, China; Completed
Department of Anesthesiology, Xijing Hospital, FMMU, XI'AN, SHANXI 710032, China; Completed
Department of Anesthesiology, Ningbo Lihuili Hospital, NINGBO, ZHEJIANG 315040, China; Completed
