Tramadol and Pain Sensitization
Information source: University Hospital, Clermont-Ferrand
Information obtained from ClinicalTrials.gov on February 12, 2009
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Pain
Intervention: Tramadol (Drug)
Phase: Phase 1
Status: Recruiting
Sponsored by: University Hospital, Clermont-Ferrand Official(s) and/or principal investigator(s):
PICKERING Gisèle, MCU-PH, pharmacology, Principal Investigator, Affiliation: unaffiliated
Overall contact:
PICKERING Gisèle, Phone: +33 4 73 17 84 10, Email: gisele.pickering@u-clermont1.fr
Summary
Tramadol is a largely used analgesic drug. Its role however on sensitization as occurs for
example in neuropathic pain is not very well known. This protocol aims therefore at studying
the effect of tramadol in a human pain model with sensitization induced by a cold stimulus,
using evoked potentials to elucidate how pain is modified when tramadol is administered.
Clinical Details
Official title: Tramadol and Pain Sensitization
Study design: Treatment, Randomized, Double Blind (Subject, Investigator), Placebo Control, Crossover Assignment, Pharmacodynamics Study
Primary outcome: Amplitude of the evoked potential elicited by a thermal stimulus on the arm with an induced hyperalgic area
Detailed description:
The study is a comparison of the analgesic of tramadol versus placebo in a pain model using
evoked potentials. Evaluation criteria will be the amplitude of the evoked potential obtained
defore and after treatment
Eligibility
Minimum age: 18 Years.
Maximum age: 40 Years.
Gender(s): Male.
Criteria:
Inclusion Criteria:
- Healthy men
- Between 18 and 40 years old
- Written consent given
Exclusion Criteria:
- Concomitant medication
- Tramadol hypersensibility
- Excessive consumption of alcohol, tobacco, coffee, tea or toxicomania
Locations and Contacts
PICKERING Gisèle, Phone: +33 4 73 17 84 10, Email: gisele.pickering@u-clermont1.fr
CIC, Clermont-Ferrand 63000, France; Recruiting
PICKERING Gisèle, MCU-PH, Pharmacology, Phone: +33 4 73 17 84 10, Email: gisele.pickering@u-clermont1.fr
Additional Information
Starting date: September 2007
Ending date: December 2007
Last updated: September 15, 2008
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