This is a double-blind, active-controlled, long-term study of a new experimental drug called
darusentan. Darusentan in not currently approved by the United States Food and Drug
Administration (FDA), which means that a doctor cannot prescribe this drug. The purpose of
this study is to evaluate the long-term safety of darusentan (optimized dose) as compared to
an active control, administered orally.
Minimum age: 35 Years.
Maximum age: 80 Years.
Gender(s): Both.
Instituto de Investigaciones Clinicas Bahia Blanca, Bahia Blanca, Argentina
Consultorios Medicos Privados S.A., Buenos Aires, Argentina
Policlinica Bancaria "9 de Julio", Buenos Aires, Argentina
Diabaid (Instituto de Asistencia Integral en Diabetes), Ciudad de Buenos Aires, Argentina
MD Investigaciones, Ciudad de Buenos Aires, Argentina
Instituto de Cardiologia de Corrientes, Corrientes, Argentina
Framingham Centro Medico, La Plata, Argentina
Instituto de Investigaciones Clinicas Mar del Plata, Mar del Plata, Argentina
Instituto de Investigaciones Clinicas de Quilmes, Quilmes, Argentina
Instituto de Investigaciones Clinicas, Rosario, Argentina
Centro de Investigaciones clincas de Litoral, Santa Fe, Argentina
Flinders Medical Centre, Bedford, Australia
Royal Perth Hospital, Perth, Australia
Private Practice of Dr. Herwig Van Aerde, Rio de Janeiro, Brazil
Alabama Internal Medicine, PC, Birmingham, Alabama 35235, United States
Greystone Medical Research, LLC, Birmingham, Alabama 35242, United States
The Heart Center, PC, Huntsville, Alabama 35801, United States
Mulberry Medical Associates, PC, Montgomery, Alabama 36106, United States
Arizona Center for Clinical Research, Glendale, Arizona 85306, United States
Cardiovascular Consultants, Ltd., Glendale, Arizona 85306, United States
Lovelace Scientific Resource, Inc., Phoenix, Arizona 85016, United States
Cochise Clinical Research, Sierra Vista, Arizona 85635, United States
Southwest Heart, Tucson, Arizona 85715, United States
HealthFirst Physicians of AR, PA dba Convenient Care Clinic, Hot Springs, Arkansas 71913, United States
NEA Clinical, Jonesboro, Arkansas 72401, United States
Arkansas Primary Care Clinic, PA, Little Rock, Arkansas 72204, United States
Medical Investigators, Inc., Little Rock, Arkansas 72205, United States
Central Cardiology Medical Clinic, Bakersfield, California 93308, United States
Highgrove Medical Center, Bakersfield, California 93301, United States
Impact Clinical Trials, Beverly Hills, California 90211, United States
VA Greater Los Angeles Healthcare System, Los Angeles, California 90073, United States
Rancho Cucamonga Clinical Trials, Rancho Cucamonga, California 91730, United States
Pacific Heart Institute, Santa Monica, California 90404, United States
Los angeles biomedical research Institute at Harbor-UCLA Medical Center, Torrance, California 90502, United States
Aurora Denver Cardiology Associates, Aurora, Colorado 80012, United States
Aurora Denver Cardiology Associates, Denver, Colorado 80218, United States
Clinical Research of South Florida, Coral Gables, Florida 33134, United States
Doctors Medical center of Walton County, Defuniak Springs, Florida 32435, United States
Broward General Medical Center, Fort Lauderdale, Florida 33316, United States
Maxine Hamilton, MD, PA, Ft Lauderdale, Florida 33316, United States
St John's Center for Clinical Research, Jacksonville, Florida 32259, United States
Private Practice of Dr. Bridget Bellingar, Largo, Florida 33773, United States
A + Research Inc., Miami, Florida 33144, United States
AppleMed Research, Inc., Miami, Florida 33155, United States
Internal Medicine Associates of South Florida, N. Miami Beach, Florida 33179, United States
Ormond Medical Arts Pharmaceutical Research Center, Ormond Beach, Florida 32174, United States
Nothwest Florida Heart Group, PA-Research Dept, Pensacola, Florida 32514, United States
Cardiovascular Center of Sarasota, Sarasota, Florida 34231, United States
Suncoast Cardiovascular Research, Inc, St Petersburg, Florida 33701, United States
Orlando Rangel, MD, PA, Tampa, Florida 33607, United States
Tampa Bay Nephrology Associates, PL, Tampa, Florida 33603, United States
AMR Research Associates, LLC, Bogart, Georgia 30622, United States
Atlanta Vascular Research Foundation, Tucker, Georgia 30084, United States
Consultants in Cardiovascular Med (CIS), Melrose Park, Illinois 60160, United States
Illinois Heart & Lunch Research Center, Normal, Illinois 61761, United States
Methodist Medical Center-Heart, Lung & Vascular Institute, Peoria, Illinois 61606, United States
Medical consultants, PC, Muncie, Indiana 47303, United States
University Medical Associates, Louisville, Kentucky 40202, United States
Dr. Jeffrey Chen, Lafayette, Louisiana 70503, United States
Louisiana Research Associates, Inc., New Orleans, Louisiana 70114, United States
Maine Research Associates, Auburn, Maine 04210, United States
PrimeCare Internal Medicine, Biddeford, Maine 04005, United States
Great Lakes Heart Center of Alpena, Alpena, Michigan 49707, United States
Internal Medicine of Northern Michigan, Petoskey, Michigan 49770, United States
Minneapolis VAMC, Minneapolis, Minnesota 55417, United States
Central Minnesota Heart Center at St. Cloud Hospital, St. Cloud, Minnesota 56303, United States
St. Paul Cardiology, St. Paul, Minnesota 55102, United States
Glacier View Cardiology, PC, Kalispell, Montana 59901, United States
Impact Clinical Trials, Las Vegas, Nevada 89106, United States
NJ Heart, Linden, New Jersey 07036, United States
New Jersey Physicians, Passaic, New Jersey 07055, United States
Lifeline Research Institute, Brooklyn, New York 11214, United States
Heart Care Center of Charlotte, Charlotte, North Carolina 28211, United States
Metrolina Internal Medicine, PA, Charlotte, North Carolina 28204, United States
Physicians East, PA, Winterville, North Carolina 27858, United States
Plaza Medical Group, PC, Oklahoma City, Oklahoma 73112, United States
Castlerock Clinical Research Consultants, LLC, Tulsa, Oklahoma 74136, United States
Integrated Medical Research PC, Ashland, Oregon 97520, United States
Blackstone Cardiology Associates, Pawtucket, Rhode Island 02860, United States
Charleston Cardiology, Charleston, South Carolina 29403, United States
Paris View Family Practice, Greenville, South Carolina 29601, United States
Internal Medicine of Greer, Greer, South Carolina 29651, United States
Scenic City Research, Cleveland, Tennessee 37311, United States
Southeast Texas Clinical Research Center, Beaumont, Texas 77702, United States
Cardiovascular Research Inst. of Dallas, Dallas, Texas 75231, United States
Galenos Research, Dallas, Texas 75251, United States
Sergio F Rovner, MD, El Paso, Texas 79935, United States
Clinical Trial Network, Houston, Texas 77074, United States
Houston Clinical Research Assoc., Houston, Texas 77090, United States
Humayum Mirza, MD, PA, Houston, Texas 77055, United States
Salim Gopalani, MD, PA, Houston, Texas 77008, United States
Innovative Research of West Florida, Hurst, Texas 76054, United States
North Texas Medical Research, Plano, Texas 75093, United States
Scott & White Memorial Hospital, Temple, Texas 76508, United States
Fletcher Allen Health Care/University of Vermont, Burlington, Vermont 05401, United States
Kamlesh N Dave Cardiology, Hopewell, Virginia 23860, United States
WVU Physicicans of Charleston, Charleston, West Virginia 25304, United States
Alpha Medical Research, LLC, Madison, Wisconsin 43717, United States
Executive Health and Research Associates, Madison, Wisconsin 53717, United States