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Interactions Between HIV Protease Inhibitors and Calcium Channel Blockers

Information source: National Institute of Allergy and Infectious Diseases (NIAID)
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: HIV Infections; Cardiovascular Diseases; Hypertension

Intervention: Indinavir sulfate (Drug); Ritonavir (Drug); Amlodipine (Drug); Diltiazem HCl (Drug)

Phase: Phase 1

Status: Completed

Sponsored by: National Institute of Allergy and Infectious Diseases (NIAID)

Official(s) and/or principal investigator(s):
Marshall Glesby, Study Chair

Summary

Diltiazem CD and amlodipine are drugs used to treat heart disease and high blood pressure. The purpose of this study is to find out if these drugs interact with the anti-HIV drugs indinavir and ritonavir. The study will also look at the safety of taking the study drugs together. Heart disease and high blood pressure are major health concerns for people with HIV. Standard treatment for these illnesses often includes calcium channel blockers (CCBs). There is a potential for significant drug interactions between CCBs and HIV protease inhibitors (PIs) that may influence the dosing, monitoring, and choosing of CCBs and PIs when used in people infected with HIV. This study will examine the drug interactions between 2 commonly used CCBs and the PI combination indinavir and ritonavir (IDV/RTV). This information should help doctors choose the appropriate treatment for high blood pressure or heart disease in people taking PIs.

Clinical Details

Official title: Evaluation of Potential Pharmacokinetic Interactions Between HIV Protease Inhibitors and Calcium Channel Blockers

Study design: Endpoint Classification: Safety/Efficacy Study, Masking: Open Label, Primary Purpose: Treatment

Detailed description: Ischemic cardiovascular disease and hypertension occur in persons with HIV infection, and the incidence and prevalence may increase over time as the infected population ages. Standard pharmacologic interventions for these illnesses often include calcium channel blockers (CCBs). Many of the calcium channel blockers are metabolized by cytochrome P450 3A4 (CYP 3A4), which is inhibited by some protease inhibitors (PIs). Thus, there is potential for clinically significant interactions between CCBs and PIs. The presence of significant drug-drug interactions may influence the dosing, monitoring, and choosing of CCBs and/or PIs when used in persons with HIV infection. Because of the potential concomitant use of CCBs with the PI combination IDV/RTV, this study will evaluate bi-directional drug-drug interactions between 2 commonly used CCBs and IDV/RTV. This information should assist clinicians in choosing the appropriate CCBs to treat hypertension or cardiovascular disease in persons taking PIs. Patients are randomized to 1 of the following 2 arms: Arm A: diltiazem CD interaction with IDV and RTV. Arm B: amlodipine interaction with IDV and RTV. From Days 1 to 7, patients take diltiazem CD (Arm A) or amlodipine (Arm B). Plasma is collected for PK over a 24-hour period beginning on Day 7. From Days 8 to 19, patients stop taking their assigned CCB and take IDV and RTV. Plasma is collected for PK over a 12-hour period on Day 19. From Days 20 to 26, patients continue to take IDV and RTV and add diltiazem CD (Arm A) or amlodipine (Arm B). Patients stop all 3 drugs after the last dose on Day 26. Plasma is collected for PK for a 24-hour period beginning on Day 26. Blood work, liver and kidney function tests, urinalysis, and an electrocardiogram (EKG) are performed at some visits.

Eligibility

Minimum age: 18 Years. Maximum age: 60 Years. Gender(s): Both.

Criteria:

Inclusion Criteria Patients may be eligible for this study if they:

- Are HIV-negative.

- Are between the ages of 18 and 60.

- Agree not to become pregnant or to impregnate and to use an acceptable form of

contraception while receiving study drugs and for 1 month after stopping study drugs. Patients who are not of reproductive potential are eligible without the contraception requirement.

- Are within 30 percent of ideal body weight.

- Weigh at least 110 lbs.

Exclusion Criteria Patients may not be eligible for this study if they:

- Have a history of any illness that requires current medical therapy.

- Have a history of any kidney disorder.

- Have any medical condition that, in the opinion of the investigator, would interfere

with the study.

- Are pregnant or breast-feeding.

- Use certain drugs within 14 days prior to study entry.

- Are allergic or sensitive to study drugs.

- Use drugs or alcohol in a way which, in the opinion of the investigator, would

interfere with the study.

- Have any abnormality on electrocardiogram within 21 days prior to study entry.

- Participate in any investigational drug studies within 21 days prior to study entry

and during study.

- Are unable to participate in pharmacokinetic visits.

- Are unable to understand or follow the fluid intake requirement during the periods of

IDV/RTV administration.

Locations and Contacts

Univ of California San Francisco, San Francisco, California 94110, United States

Stanford Univ Med Ctr, Stanford, California 943055107, United States

Univ of Colorado Health Sciences Ctr, Denver, Colorado 80262, United States

Johns Hopkins Hosp, Baltimore, Maryland 21287, United States

Univ of Minnesota, Minneapolis, Minnesota 55455, United States

Washington Univ (St. Louis), St. Louis, Missouri 63108, United States

Cornell Univ Med Ctr, New York, New York 10021, United States

Univ of Rochester Medical Center, Rochester, New York 14642, United States

Univ of Cincinnati, Cincinnati, Ohio 452670405, United States

Additional Information

Click here for more information about indinavir sulfate

Click here for more information about ritonavir

Haga clic aquí para ver información sobre este ensayo clínico en español.

Related publications:

Yunis NA, Stone VE. Cardiac manifestations of HIV/AIDS: a review of disease spectrum and clinical management. J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Jun 1;18(2):145-54. Review.

Henry K, Melroe H, Huebsch J, Hermundson J, Levine C, Swensen L, Daley J. Severe premature coronary artery disease with protease inhibitors. Lancet. 1998 May 2;351(9112):1328.

Cattelan AM, Trevenzoli M, Sasset L, Rinaldi L, Balasso V, Cadrobbi P. Indinavir and systemic hypertension. AIDS. 2001 Apr 13;15(6):805-7.

Passalaris JD, Sepkowitz KA, Glesby MJ. Coronary artery disease and human immunodeficiency virus infection. Clin Infect Dis. 2000 Sep;31(3):787-97. Epub 2000 Oct 4. Review.


Last updated: May 17, 2012

Page last updated: August 23, 2015

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