RATIONALE: Radiation therapy uses high energy x-rays to damage tumor cells. Drugs used in
chemotherapy use different ways to stop tumor cells from dividing so they stop growing or
die. Combining radiation therapy with chemotherapy may kill more tumor cells. It is not yet
known which chemotherapy regimen is more effective when combined with radiation therapy for
PURPOSE: Randomized phase III trial to compare two combination chemotherapy treatments plus
radiation therapy in treating children with newly diagnosed medulloblastoma.
OUTLINE: This is a randomized study. Patients are stratified by participating institution.
Following surgery, patients are randomized to one of two groups. The first group receives
craniospinal irradiation followed by a boost to the primary tumor. Beginning within 1 week
after initiation of radiotherapy, patients receive vincristine weekly for 8 doses. Beginning
6 weeks after the completion of radiotherapy, patients receive adjuvant
lomustine/vincristine/cisplatin every 6 weeks for a total of 8 courses. The second group
receives craniospinal irradiation plus vincristine as above, followed by adjuvant
cyclophosphamide/vincristine/cisplatin every 6 weeks for a total of 8 courses. Patients are
followed every 3 months for 1 year, every 6 months for 2 years, then annually.
PROJECTED ACCRUAL: It is anticipated that 240-300 patients will be entered over 4 years.
Minimum age: 3 Years.
Maximum age: 22 Years.
University of Puerto Rico School of Medicine Medical Sciences Campus, San Juan 00936-5067, Puerto Rico
Clinique de Pediatrie, Geneva 1211, Switzerland
British Columbia Children's Hospital, Vancouver, British Columbia V6H 3V4, Canada
Children's Hospital Los Angeles, Los Angeles, California 90027-0700, United States
Children's Hospital of Orange County, Orange, California 92668, United States
Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, California 90095-1781, United States
Long Beach Memorial Medical Center, Long Beach, California 90806, United States
UCSF Cancer Center and Cancer Research Institute, San Francisco, California 94115-0128, United States
Children's Hospital of Denver, Denver, Colorado 80218, United States
Children's National Medical Center, Washington, District of Columbia 20010-2970, United States
University of Chicago Cancer Research Center, Chicago, Illinois 60637, United States
Indiana University Cancer Center, Indianapolis, Indiana 46202-5265, United States
University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242, United States
Via Christi Regional Medical Center, Wichita, Kansas 67214, United States
MBCCOP - LSU Medical Center, New Orleans, Louisiana 70112, United States
University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan 48109-0752, United States
Mayo Clinic Cancer Center, Rochester, Minnesota 55905, United States
University of Minnesota Cancer Center, Minneapolis, Minnesota 55455, United States
Children's Mercy Hospital, Kansas City, Missouri 64108, United States
University of Nebraska Medical Center, Omaha, Nebraska 68198-3330, United States
St. Joseph's Hospital and Medical Center, Paterson, New Jersey 07503, United States
Herbert Irving Comprehensive Cancer Center, New York, New York 10032, United States
Memorial Sloan-Kettering Cancer Center, New York, New York 10021, United States
NYU School of Medicine's Kaplan Comprehensive Cancer Center, New York, New York 10016, United States
Lineberger Comprehensive Cancer Center, UNC, Chapel Hill, North Carolina 27599-7295, United States
IWK Grace Health Centre, Halifax, Nova Scotia B3J 3G9, Canada
Children's Hospital Medical Center - Cincinnati, Cincinnati, Ohio 45229-3039, United States
Children's Hospital of Columbus, Columbus, Ohio 43205-2696, United States
Ireland Cancer Center, Cleveland, Ohio 44106-5065, United States
Doernbecher Children's Hospital, Portland, Oregon 97201-3098, United States
Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, United States
Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania 15213, United States
Saint Jude Children's Research Hospital, Memphis, Tennessee 38105-2794, United States
Vanderbilt Cancer Center, Nashville, Tennessee 37232-6838, United States
University of Texas - MD Anderson Cancer Center, Houston, Texas 77030, United States
Huntsman Cancer Institute, Salt Lake City, Utah 84132, United States
Cancer Center, University of Virginia HSC, Charlottesville, Virginia 22908, United States
Children's Hospital and Regional Medical Center - Seattle, Seattle, Washington 98105, United States
Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, United States
Princess Margaret Hospital for Children, Perth, Western Australia 6001, Australia
University of Wisconsin Comprehensive Cancer Center, Madison, Wisconsin 53792, United States
Turgut M. Cerebellar mutism. J Neurosurg Pediatrics. 2008 Mar;1(3):262.
Robertson PL, Muraszko KM, Holmes EJ, Sposto R, Packer RJ, Gajjar A, Dias MS, Allen JC; The Children's Oncology Group. Incidence and severity of postoperative cerebellar mutism syndrome in children with medulloblastoma: a prospective study by the Children's Oncology Group. J Neurosurg. 2006 Dec;105(6):444-51.