Antibiotic Dosing in Pediatric Intensive Care
Information source: University Hospital, Ghent
ClinicalTrials.gov processed this data on August 23, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Pharmacokinetics; Amoxicillin-clavulanate; Piperacillin-tazobactam
Intervention: blood sampling (Procedure)
Phase: N/A
Status: Recruiting
Sponsored by: University Hospital, Ghent Overall contact: Pieter De Cock, PharmD, Phone: +32 9 332 29 69, Email: pieter.decock@uzgent.be
Summary
Pharmacokinetics of antibiotics in critically ill neonates, infants and children
Clinical Details
Official title: Antibiotic Dosing in Pediatric Intensive Care
Study design: Time Perspective: Prospective
Primary outcome: To investigate if first-dose blood concentrations with maximum antimicrobial activity are achieved with current dosing regimens.To investigate if steady-state blood concentrations with maximum antimicrobial activity are achieved with current dosing regimens.
Secondary outcome: To compare measured first-dose blood concentrations with predefined pharmacodynamic targets (Time above MIC)To compare measured steady-state blood concentrations with predefined pharmacodynamic targets (Time above MIC)
Eligibility
Minimum age: N/A.
Maximum age: 16 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- patients admitted to the pediatric intensive care unit
- patient age/weight : 1,8 kg-15 years
- patient receiving antibiotic treatment (piperacillin-tazobactam,
amoxicillin-clavulanate) via intermittent infusion regimen according to institutional
treatment guidelines
- intra-arterial or intravenous access other than the drug infusion line available for
blood sampling (arterial line is preferred)
Exclusion Criteria:
- no catheter in place for blood sampling
- absence of parental/patient consent
- known hypersensitivity to beta-lactam antibiotics or glycopeptides
- extracorporeal circuit (haemodialysis, ECMO, peritoneal dialysis )
Locations and Contacts
Pieter De Cock, PharmD, Phone: +32 9 332 29 69, Email: pieter.decock@uzgent.be
Ghent University Hospital, Hospital Pharmacy, Ghent 9000, Belgium; Recruiting Pieter De Cock, PharmD, Phone: +3293322969, Email: pieter.decock@uzgent.be Pieter De Cock, PharmD, Sub-Investigator Annick de Jaeger, MD, Principal Investigator Dominique Biarent, MD, Principal Investigator Jozef De Dooy, MD, Principal Investigator
Additional Information
Starting date: May 2012
Last updated: May 26, 2015
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