Succinylcholine vs Rocuronium for Prehospital Emergency Intubation

Condition(s) targeted: Coma; Major Trauma; Respiratory Distress; Shock

Intervention: Succinylcholine : 1mg/kg (Drug); Rocuronium : 1.2 mg/kg (Drug)

Phase: Phase 4

Status: Recruiting

Sponsored by: Centre Hospitalier Universitaire de la Réunion

Official(s) and/or principal investigator(s):
Xavier Combes, MD, Principal Investigator, Affiliation: CHU de La Réunion

Overall contact:
Xavier Combes, Phone: 02 62 90 60 46, Email: x.combes.samu974@chu-reunion.fr

All adult patients with spontaneous cardiac activity and requiring tracheal intubation in the pre hospital emergency context will be included in order to compare the use of succinylcholine vs Rocuronium for prehospital emergency intubation.

Official title: Succinylcholine vs Rocuronium for Prehospital Emergency Intubation : a Randomized Trial

Study design: Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Subject), Primary Purpose: Treatment

Primary outcome: First-pass intubation success rate

Secondary outcome:

Incidence of difficult intubation

Intubation conditions assessment

Need for alternate airway devices

early intubation-related complications

Detailed description: All adult patients with spontaneous cardiac activity and requiring tracheal intubation in the pre hospital emergency context will be included. All intubation will be performed by an emergency physician or a nurse specialized in anesthesia. For patients with spontaneous cardiac activity, rapid sequence intubation will be performed to allow intubation. Comparisons studied will be : Intubation success rate at the first laryngoscopy, glottis exposure assessed by Cormack and Lehane classification, difficult intubation rate assessed by the Intubation Difficult Score (IDS), the conditions of intubation assessed by the Copenhagen score, the need for alternative airway techniques and the immediate post intubation complications rate as vomiting, dental trauma, pulmonary inhalation, arterial desaturation , hypotension episodes and cardiac arrest occurrence.

Minimum age: 18 Years. Maximum age: N/A. Gender(s): Both.

Criteria:

Inclusion Criteria:

- All adult patients with spontaneous cardiac activity and requiring tracheal

intubation in the pre hospital emergency context Exclusion Criteria:

- Patients in cardiac arrest;

- Patients under-18s;

- Patients under guardianship ;

- Pregnancy known;

- Patients with cons to one of the following three drugs: rocuronium, succinylcholine,

sugammadex;

- Patients not affiliated to a social security scheme (beneficiary or legal).

Xavier Combes, Phone: 02 62 90 60 46, Email: x.combes.samu974@chu-reunion.fr

CHU Avicenne, Bobigny, France; Not yet recruiting
Hayatte Akodad, MD, Email: hayatte.akodad@gmail.com
Hayatte Akodad, MD, Principal Investigator

CHU Henri Mondor, Créteil, France; Recruiting
Charlotte Chollet-Xémard, MD, Email: charlotte.chollet@hmn.aphp.fr
Charlotte CHOLLET-XEMARD, MD, Principal Investigator

CHU de Dijon, Dijon, France; Not yet recruiting
Marc Freysz, MD, Email: marc.freysz@chu-dijon.fr

CHU Raymond Poincaré, Garches, France; Not yet recruiting
Thomas Loeb, Email: thomas.loeb@rpc.aphp.fr

CH Gonesse, Gonesse, France; Recruiting
philippe lakhnati, MD, Email: philippe.lakhnati@gmail.com
Philippe LAKHNATI, MD, Principal Investigator

CHRU de Lille, Lille, France; Not yet recruiting
eric wiel, MD, Email: eric.wiel@chru-lille.fr

CH Marc Jacquet, Melun, France; Recruiting
Laurent Rebillard, MD, Email: laurent.rebillard@ch-melun.fr
Laurent Rebillard, MD, Principal Investigator

CHU de Nîmes, Nîmes, France; Not yet recruiting
Xavier Bobbia, MD, Email: xavier.bobbia@chu-nimes.fr

CHU Hôtel-Dieu, Paris, France; Not yet recruiting
Juliette Deutsch, MD, Email: juliette.deutsch@htd.aphp.fr

CHU Lariboisière, Paris, France; Not yet recruiting
Papa Gueye, MD, Email: papa.gueye@lrb.aphp.fr

CHU Necker, Paris, France; Recruiting
Benoit Vivien, MD, Email: benoit.vivien@nck.aphp.fr

CHU Pitié-Salpêtrière, Paris, France; Recruiting
Patrick Ecollan, MD, Email: patrick.ecollan@psl.aphp.fr
Patrick ECOLLAN, MD, Principal Investigator

CH René Dubos, Pontoise, France; Recruiting
Agnès Ricard-Hibon, MD, Email: agnes.ricard-hibon@ch-pontoise.fr
Agnès RICARD-HIBON, MD, Principal Investigator

CH Annecy, Pringy, France; Not yet recruiting
Dominique Savary, MD, Email: dsavary@ch-annecy.fr

CHU Toulouse - Hôpital PURPAN, Toulouse, France; Not yet recruiting
Vincent Bounes, MD, Email: bounes.v@chu-toulouse.fr

CHU de La Réunion, Saint Denis, La Réunion 97405, France; Recruiting
Xavier Combes, Phone: 02 62 90 20 72, Email: x.combes.samu974@chu-reunion.fr
Xavier Combes, Principal Investigator
Marielle BASTY-GHUYSEN, Sub-Investigator
Pascal BAUDON, Sub-Investigator
Laurent CHEN-CHI-SONG, Sub-Investigator
Francois DALTROFF, Sub-Investigator
Amelie DARMEDRU, Sub-Investigator
Emilie FENETRIER, Sub-Investigator
Magali FERRY, Sub-Investigator
Bertrand GUIHARD, Sub-Investigator
Nasser LAKEBAL, Sub-Investigator
Arnaud MICHALON, Sub-Investigator
Sophie PREDOUR, Sub-Investigator
Anna SALNIKOVA, Sub-Investigator
Jerome SUDRIAL, Sub-Investigator
Frederic NATIVEL, MD, Sub-Investigator

CHU de la Réunion, Saint Pierre, La Réunion, France; Recruiting
Pierre Jean Marianne, Email: pierre-jean.marianne-cassou@chu-reunion.fr
Pierre Jean Marianne, Principal Investigator
Thibault ADENIS, Sub-Investigator
Perine BOURDIN, Sub-Investigator
Hakim CHABANE, Sub-Investigator
Thomas MASSEGUIN, Sub-Investigator
Flore PINEAU, Sub-Investigator
Antoine POUPEL, Sub-Investigator
Adrien VAGUE, Sub-Investigator
Lena GUILLOU, MD, Sub-Investigator
Tatjana JEKIC, MD, Sub-Investigator
Paul LAFORET, MD, Sub-Investigator
Marion LENOIR, MD, Sub-Investigator
Catherine MANGIN, MD, Sub-Investigator
Jean Manuel PIERNA, MD, Sub-Investigator
Roland RAKOTOSON, MD, Sub-Investigator

Starting date: December 2013
Last updated: July 28, 2015