Infarct size is a major determinant of prognosis after Acute Myocardial Infarction (AMI).
The investigators recently reported that cyclosporine A, when administered immediately prior
to percutaneous coronary intervention (PCI), can significantly reduce infarct size in STEMI
(ST Elevation acute Myocardial Infarction) patients. The objective of the present study is
to determine whether cyclosporine can improve STEMI patient clinical outcome. Nine-hundred
and seventy two patients with ST elevation MI will be entered into a multicentre,
randomized, placebo-controlled, double-blinded study. They will receive one single injection
of cyclosporine A (CicloMulsion, verum) or an equivalent volume of placebo prior to
reperfusion therapy by PCI. The incidence of the combined endpoint (mortality,
hospitalization for heart failure, left ventricular (LV) remodeling) will be assessed at one
year and three years after treatment.
Minimum age: 18 Years.
Maximum age: N/A.
Gender(s): Both.
Algemeen Ziekenhuis Sint-Jan Brugge, Brugge 8000, Belgium
Chu Charleroi, Charleroi 6000, Belgium
Hôpital universitaire d'Anvers (UZA), Edegem 2650, Belgium
CHU Mont-Godinne, Yvoir 5530, Belgium
Clinique ESQUIROL - SAINT-HILAIRE, Agen 47000, France
Centre Hospitalier du Pays D'Aix, Aix En Provence 13616, France
Centre Hospitalier Universitaire d'Angers, Angers 49033, France
Centre Hospitalier d'Annecy, Annecy 74011, France
Hôpital Henri Duffaut, Avignon 84000, France
Clinique Lafourcade, Bayonne 64100, France
Centre Hospitalier Universitaire, Brest 29609, France
Hopital Louis Pradel, Hospices Civils de Lyon, Bron cedex 69677, France
CHRU- Hôpital de la Côte de Nacre, Caen 14033, France
Centre Hospitalier General, Chartres 28018, France
CHU - Hôpital Gabriel Montpied, Clermont Ferrand 63003, France
CH de Compiègne, Compiegne 60321, France
CH Henri MONDOR, Creteil 94010, France
Hôpital du Bocage, Dijon 21034, France
Hôpital A. MICHALLON - CHU, Grenoble 38043, France
Centre Hospitalier General, Hagueneau 67504, France
CHRU - Hôpital Cardiologique Calmette, Lille, France
Centre Hospitalier St Luc St Joseph, Lyon 69365, France
Clinique de la Sauvegarde, Lyon 69009, France
Institut Jacques Cartier, Massy 91300, France
CHU Arnaud de Villeneuve, Montpellier 34295, France
Clinique du Millénaire, Montpellier 34960, France
CHU de Mulhouse, Mulhouse 68100, France
Clinique du Diaconat, Mulhouse 69607, France
Hôpital Guillaume et René Laennec, Nantes 44093, France
CHU de Nîmes, Nimes 30029, France
Polyclinique des Fleurs, Ollioules 83192, France
APHP Hôpital Bichat, Paris 75018, France
CH de Pau, PAU 64011, France
Hôpital Haut Lévêque, Pessac 33604, France
Hôpital Claude Galien, Quincy Sous Senart 91480, France
Hôpital Pontchaillou, Rennes 35003, France
Hôpital Charles NICOLLE, Rouen 76031, France
Hôpitaux Universitaires, Nouvel Hôpital Civil, Strasbourg 67091, France
Clinique de l'Ormeau - CCV des Pyrénées, Tarbes 65000, France
CHU de Rangueil, Toulouse 31043, France
CHRU de Tours, Tours 37044, France
Clinique Saint Gatien, Tours 37042, France
Hôpital Brabois - CHU Nancy, Vandoeuvre Les Nancy 54511, France
Clinique du Tonkin, Villeurbanne 69100, France
Hospital Universitari Vall d'Hebron, Barcelona 08035, Spain