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Esmolol or Nitroglycerin Infusion for Blood Pressure Control Prior to Cardiopulmonary Bypass (CPB) in Cardiac Surgery

Information source: Loma Linda University
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Hypertension

Intervention: nitroglycerin (Drug); esmolol (Drug)

Phase: N/A

Status: Completed

Sponsored by: Loma Linda University

Official(s) and/or principal investigator(s):
Richard L Applegate II, MD, Principal Investigator, Affiliation: Loma Linda University

Summary

This is an investigator initiated, sponsored, open label, prospective randomized controlled trial to be performed in adult patients undergoing scheduled cardiac surgery. Patients will be randomized to esmolol infusion or nitroglycerin infusion for control of hypertension that occurs during cardiac surgery from induction of anesthesia to initiation of cardiopulmonary bypass (CPB).

Clinical Details

Official title: Esmolol or Nitroglycerin Infusion for Blood Pressure Control Prior to Cardiopulmonary Bypass(CPB) in Cardiac Surgery: a Randomized, Controlled Trial

Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Primary outcome: Esmolol or Nitroglycerin Infusion for Blood Pressure Control Prior to Cardiopulmonary Bypass in cardiac surgery: a randomized, clinical trial

Secondary outcome: Title: Systolic or diastolic hypertension; systolic hypotension

Eligibility

Minimum age: 18 Years. Maximum age: 85 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- adult patients scheduled for cardiac surgery at LLUMC University Hospital will be

eligible for participation in this study. Exclusion Criteria: 1. severe LV (left ventricle)dysfunction (EF < 35%). 2. emergency procedures. 3. procedures with combined carotid artery surgery. 4. patients at high risk for stroke. 5. hemodynamically significant dysrhythmias. 6. pre-existing atrial fibrillation or high degree AV (atrioventricular block). 7. pacemaker dependency. 8. known sensitivity to beta blockers. 9. patient refusal.

Locations and Contacts

Loma Linda University, Loma Linda, California 92354, United States
Additional Information

Starting date: December 2010
Last updated: September 9, 2014

Page last updated: August 23, 2015

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