Clinical, Airway Inflammatory, and HRA Phenotypes, in Preschool Children With Acute Asthmatic Attack Presenting to the ED.
Information source: Wolfson Medical Center
ClinicalTrials.gov processed this data on August 20, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Asthma
Phase: N/A
Status: Completed
Sponsored by: Wolfson Medical Center Official(s) and/or principal investigator(s): Avigdor Mandelberg, MD, Study Chair, Affiliation: The Sackler School of Medicine, Tel Aviv University, Israel
Summary
Clinical, Airway Inflammatory, and HRA Phenotypes, in preschool children with acute
asthmatic attack presenting to the ED.
Background:
Children under the age of 5 years have the highest hospitalization rate of asthma. The most
common causes of acute exacerbations of asthma requiring urgent medical care are viral
respiratory infections. Most of these children < 6 y old are not atopic.
The inflammatory response to these mostly viral-induced asthmatic attacks is not well
characterized in the literature. Moreover it is not known whether different kind of
inflammatory responses exist in this population and how this correlate to clinical outcomes
and clinical phenotypes in preschool children presenting ti the ED with acute asthmatic
attack.
Therefore, the purpose of the present study is to:
Investigate the characterization of induced sputum cytology in preschool children with acute
asthmatic attack and whether there is correlation between specific sputum cytology and
response to therapy and to investigate airways hyper-responsiveness to adenosine
5'-monophosphate and to metacholine in pre school children 2-6 y old at 2 weeks and at 3
month following acute asthmatic exacerbation and look for correlation with response to
treatment and sputum cytology. Clinical phenotypes of this patient population will also be
investigated.
Clinical Details
Official title: Clinical, Airway Inflammatory, and HRA Phenotypes, in Preschool Children With Acute Asthmatic Attack Presenting to the ED.
Study design: Time Perspective: Prospective
Primary outcome: airways inflammatory phenotypepost attack bronchial hyperreactivity to adenosine 5'-monophosphate and to metacholine
Secondary outcome: Relationship between post attack bronchial hyperreactivity to adenosine 5'-monophosphate and to metacholine and the response to treatment and cytologic phenotypes.relationship between cytologic phenotypes and response to treatment. clinical phenotype
Detailed description:
Clinical, Airway Inflammatory, and HRA Phenotypes, in preschool children with acute
asthmatic attack presenting to the ED.
Background:
Children under the age of 5 years have the highest hospitalization rate of asthma. The most
common causes of acute exacerbations of asthma requiring urgent medical care are viral
respiratory infections. Most of these children < 6 y old are not atopic.
The inflammatory response to these mostly viral-induced asthmatic attacks is not well
characterized in the literature. Moreover it is not known whether different kind of
inflammatory responses exist in this population and how this correlate to clinical outcomes
and clinical phenotypes.
Therefore, the purpose of the present study is to:
Investigate the characterization of induced sputum cytology, bronchial hyper-responsiveness
(BHR, and clinical phenotypes in preschool children with acute asthmatic attack presenting
to the ED and whether there is correlation between specific sputum cytology and response to
therapy.
and to investigate airways hyper-responsiveness (BHR)to adenosine 5'-monophosphate and to
metacholine in pre school children 2-6 y old at 2 weeks and at 3 month following acute
asthmatic exacerbation and look for correlation with response to treatment and sputum
cytology.
Clinical phenotypes of this patient population will also be investigated. Clinical
characteristics of the preschool children presenting to the ED with asthmatic attack will be
compared to normal controls recruited from ambulatory clinics at the same area.
Eligibility
Minimum age: 1 Year.
Maximum age: 6 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- children, age: 1-6 years old
- presenting to the ER with acute wheezing episode.
Exclusion Criteria:
- Any chronic (lung, cardiac, immunologic, neurologic) disease
Locations and Contacts
The Edith Wlofson Medical Center, Holon, Israel
Additional Information
Starting date: January 2009
Last updated: September 4, 2011
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