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Chlorhexidine & Pneumonia in Nursing Home Residents

Information source: University of Louisville
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Pneumonia; Respiratory Infection

Intervention: chlorhexidine (Drug); Placebo mouthwash (Drug)

Phase: Phase 1

Status: Active, not recruiting

Sponsored by: University of Louisville

Official(s) and/or principal investigator(s):
Catherine J Binkley, DDS, PhD, Principal Investigator, Affiliation: University of Louisville


The purpose of this study is determine if topical oral application of a chlorhexidine antimicrobial spray will significantly reduce pneumonia and respiratory infections, and improve oral health compared to a placebo solution in nursing home residents.

Clinical Details

Official title: Effect of Topical Oral Chlorhexidine in Reducing Pneumonia in Nursing Home Residents

Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Prevention

Primary outcome: Pneumonia

Secondary outcome:

Respiratory pathogens

Plaque and Gingival Indices


Minimum age: 65 Years. Maximum age: N/A. Gender(s): Both.


Inclusion Criteria: 1. Participants must be at least 65 years old. 2. Be dependent in 2 or more Activities of Daily Living as noted on the nursing home

resident's Minimum Data Set - One must be ADL J- Personal Hygiene.

3. Have natural teeth and/or wear complete or partial dentures. 4. Expected to be a resident in a nursing home for two years. Exclusion Criteria: 1. Existing pneumonia. 2. History of chlorhexidine reaction or allergy and/or multiple medication or substance allergies. 3. Receiving chlorhexidine oral application at enrollment as prescribed by physician or dentist.

Locations and Contacts

University of Louisville, Louisville, Kentucky 40202, United States
Additional Information

Starting date: January 2006
Last updated: August 6, 2009

Page last updated: August 23, 2015

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