Impact of Anti-Giardia and Antihelmintic Treatment on Infant Growth in Bangladesh
Information source: University of Cambridge
Information obtained from ClinicalTrials.gov on June 20, 2008
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Giardiasis
Intervention: Anti-Giardia and antihelmintic treatment (secnidazole or albendazole) (Drug); Anti-Giardia treatment only (secnidazole or albendazole) (Drug); Control group (placebo) (Drug)
Phase: N/A
Status: Completed
Sponsored by: University of Cambridge Official(s) and/or principal investigator(s):
Nicholas C Mascie-Taylor, ScD, Study Chair, Affiliation: Department of Biological Anthropology, University of Cambridge
Summary
This longitudinal study aimed to assess whether regular anti-Giardia and antihelmintic
treatment improved growth and small intestinal mucosal function of rural Bangladeshi
infants.
Clinical Details
Official title: Effects of Anti-Giardia and Antihelmintic Treatment on Infant Nutritional and Biochemical Status and Intestinal Permeability in Rural Bangladesh
Study design: Treatment, Randomized, Double Blind (Subject, Caregiver), Placebo Control, Parallel Assignment, Efficacy Study
Primary outcome: nutritional status
Secondary outcome: intestinal permeability
Detailed description:
A randomised double-blind controlled intervention of 36 weeks duration was conducted in a
rural community located 40kms north-west of Dhaka, the capital of Bangladesh. Infants aged
between 3 and 11 months were randomly assigned to either receiving anti-Giardia and
antihelmintic treatment, or anti-Giardia treatment only, or a control group receiving
placebos. Weight and supine length were recorded every 4 weeks. Every 12 weeks intestinal
permeability (L/M ratio), haemoglobin, plasma albumin, alpha-1-acid glycoprotein,
immunoglobulin G and Giardia intestinalis specific IgM titre (GSIgM) and eggs of the three
common geohelminths and Giardia intestinalis cysts were determined.
Eligibility
Minimum age: 3 Months.
Maximum age: 15 Months.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- infants living in the study area
Locations and Contacts
National Institute of Preventive and Social Medicine, Mohakhali, Dhaka 1212, Bangladesh
Additional Information
Starting date: June 2003
Ending date: December 2006
Last updated: February 4, 2008
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