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Topical Corticosteroids on the Incidence of Postinflammatory Hyperpigmentation After QsNdYAG Laser

Information source: Mahidol University
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Lentigines; Post Inflammatory Hyperpigmentation

Intervention: topical 0.05% Clobetasol propionate ointment (Drug); Q switched Nd:YAG laser 532 nm (Device)

Phase: N/A

Status: Active, not recruiting

Sponsored by: Mahidol University

Official(s) and/or principal investigator(s):
Woraphong Manuskiatti, M.D., Principal Investigator, Affiliation: Department of Dermatology, Siriraj Hospital


To investigate the benefit of the application of topical high potency steroid on the incidence of post inflammatory hyperpigmentation after laser treatment.

Clinical Details

Official title: Effect of Topical Corticosteroids on the Incidence of Postinflammatory Hyperpigmentation Following Q-switched Nd:YAG 532 nm Laser for Treatment of Facial Lentigines - A Pilot Study

Study design: Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Investigator), Primary Purpose: Treatment

Primary outcome: The incidence of post inflammatory hyperpigmentation

Secondary outcome:

Side effects of topical steroid

The patients satisfaction

Detailed description:

- The incidence of post inflammatory hyperpigmentation (PIH) after treating lentigines

with Q-switched Nd: YAG laser was 78. 3%.

- It has been found that the incidence of PIH decreased to 40% after applied topical high

potency steroid 2 days after the laser treatment.

- By these anti-inflammatory and anti-PIH effects of the high potency steroid, the

investigators aimed that the application of steroid 2 days before and 2 days after the laser treatment would be better reduction in the incidence of PIH after Q-switched Nd: YAG laser.


Minimum age: 18 Years. Maximum age: 60 Years. Gender(s): Both.


Inclusion Criteria:

- Having multiple lentigines on both sides of the face

- Fitzpatrick skin phototype 3-5

Exclusion Criteria:

- Patients with lesions with any clinical suspicion of being pre-cancerous or skin

malignancies of any kind

- Patients who have photosensitive dermatoses

- Pregnancy and lactation woman

- Patients with wound infections (herpes, other) on the day of treatment

- Patients with moderate and severe inflammatory acne, Immunosuppressed patients,

history of vitiligo

- Patients with unrealistic concerns/expectations and inability to do the appropriate

post-operative care

Locations and Contacts

Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand
Additional Information

Starting date: February 2015
Last updated: July 7, 2015

Page last updated: August 23, 2015

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