Analgesic Benefits of Perineural Versus Intravenous Dexamethasone in Patients Receiving Sciatic Nerve Block
Information source: Northwestern University
ClinicalTrials.gov processed this data on August 23, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Fracture of Ankle
Intervention: Dexamethasone (Drug); Dexamethasone (Drug); Saline (Drug)
Phase: Phase 4
Status: Completed
Sponsored by: Northwestern University Official(s) and/or principal investigator(s): Rohit Rahangdale, MD, Principal Investigator, Affiliation: Northwestern University, Feinberg School of Medicine
Summary
Patients scheduled to have foot and ankle surgery will typically receive a single shot
sciatic nerve block to serve as the primary anesthetic and as part of a multi-modal
post-operative analgesic plan. The investigators are investigating the use of perineural
dexamethasone together with local anesthetics can improve the quality of recovery for
patients receiving sciatic nerve blocks for foot and ankle surgery.
Clinical Details
Official title: The Effects of Perineural Versus Intravenous Dexamethasone on Sciatic Nerve Blockade Outcomes
Study design: Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator), Primary Purpose: Supportive Care
Primary outcome: Quality of Recovery
Secondary outcome: Opioid ConsumptionPain Scores
Detailed description:
Patients scheduled to have foot and ankle surgery will typically receive a single shot
sciatic nerve block to serve as the primary anesthetic and as part of a multi-modal
post-operative analgesic plan. Perineural dexamethasone has been investigated as an adjuvant
for brachial plexus nerve blocks but its effect on sciatic nerve block outcomes has yet to
be determined. More importantly, it is not known whether the beneficial effect of perineural
dexamethasone on analgesia duration leads to a better quality of surgical recovery. We
hypothesized that perineural dexamethasone leads to a better quality of postsurgical
recovery than intravenous dexamethasone or saline control.
Eligibility
Minimum age: 18 Years.
Maximum age: 70 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- ASA 1-3 patients who are presenting for foot and ankle surgery and are candidates for
a single injection sciatic nerve block to provide postoperative analgesia.
- Surgery confined to the foot and ankle.
- Patients aged 18-70 years.
Exclusion Criteria:
- ASA Classification of 4 or higher.
- Pre-existing neuropathy
- Coagulopathy
- Infection at the site
- Diabetes
- Non-English speaking or reading patients
- Systemic use of corticosteroids within 6 months of surgery
- Chronic opioid use
- Pregnancy
- Large (>3cm) skin incision around the medial aspect of the foot
- Any other contra-indication to regional anesthesia
Locations and Contacts
Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611, United States
Additional Information
Starting date: June 2012
Last updated: November 12, 2014
|