Study of the Distractibility Syndrome in Patients With Progressive Supranuclear Palsy
Information source: Groupe Hospitalier Pitie-Salpetriere
Information obtained from ClinicalTrials.gov on November 03, 2008
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Supranuclear Palsy, Progressive
Intervention: donepezil (Drug)
Phase: Phase 2
Status: Recruiting
Sponsored by: Groupe Hospitalier Pitie-Salpetriere Official(s) and/or principal investigator(s):
Bertrand Gaymard, MD, PhD, Principal Investigator, Affiliation: INSERM-U679
Overall contact:
Bertrand Gaymard, MD, PhD, Phone: 33-142162218, Email: gaymard@ccr.jussieu.fr
Summary
The syndrome of distractibility is a behavioral disorder induced by a lesion or a dysfunction
of the frontal lobe. This sign is frequent in patients with progressive supranuclear palsy
(PSP), a neurodegenerative disorder with severe neuronal loss in the prefrontal cortex and
cholinergic systems, in particular in the Meynert basalis nucleus. This could participate in
the occurrence of the distractibility in these patients. The aim of this study is to evaluate
the effect of the donepezil, an anticholinesterase, on the distractibility in PSP patients,
by using oculomotor and neuropsychological assessments.
Clinical Details
Official title: Study of the Distractibility Syndrome in Patients With Progressive Supranuclear Palsy
Study design: Treatment, Randomized, Double-Blind, Placebo Control, Crossover Assignment, Efficacy Study
Eligibility
Minimum age: 30 Years.
Maximum age: 80 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- Patients with PSP
- Age > 30 years old
- Disease duration < 5 years
- Mini mental state (MMS) > 24
- Antisaccades %: 40-80%
Exclusion Criteria:
- Other parkinsonian syndromes
- MMS < 24
Locations and Contacts
Bertrand Gaymard, MD, PhD, Phone: 33-142162218, Email: gaymard@ccr.jussieu.fr
Centre d'Investigation Clinique-HÔPITAL PITIÉ-SALPETRIERE, PARIS 75013, France; Recruiting
Marie-Laure Welter, MD, Phone: 33-42161950, Email: marie-laure.welter@psl.aphp.fr
Bertrand Gaymard, MD, PhD, Phone: 33-142162218, Email: gaymard@ccr.jussieu.fr
Bertrand Gaymard, MD, PhD, Principal Investigator
Additional Information
Last updated: September 12, 2007
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