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Effect of the Salbutamol on Mechanical Properties of Respiratory System

Information source: Rio de Janeiro State University
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Smoking; Airway Obstruction

Intervention: Salbutamol sulphate (Drug)

Phase: N/A

Status: Recruiting

Sponsored by: Rio de Janeiro State University

Official(s) and/or principal investigator(s):
Gerusa M Costa, MSc, Principal Investigator, Affiliation: State University of Rio de Janeiro
Pedro L Melo, PhD, Study Director, Affiliation: Laboratory biomedical instrumentation

Overall contact:
Agnaldo J Lopes, PhD, Phone: 55+(21) 98536162, Email: phel.lop@uol.com.br


The aim of this study is to assess the bronchodilator response of salbutamol on respiratory mechanics of healthy individuals, smokers and COPD with varying degrees of airway obstruction.

Clinical Details

Official title: Effect of the Use of Salbutamol on the Mechanical Properties of the Respiratory System of Healthy Individuals, Smokers and COPD Patients

Study design: Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science

Primary outcome: Respiratory function test

Secondary outcome: Salbutamol

Detailed description: Clinical evaluation will be conducted and anthropometric measurements, then the pulmonary function tests: forced oscillation technique (FOT), whole body plethysmography, spirometry and-administration of salbutamol aerosol for assessment of bronchodilator response. After 20 minutes, the individual will be evaluated again following the same sequence.


Minimum age: 40 Years. Maximum age: N/A. Gender(s): Both.


Inclusion Criteria:

- healthy individuals, smokers and patients with chronic obstructive pulmonary disease.

Exclusion Criteria:

- healthy subjects: no history of smoking respiratory infection and disease respiratory

- smokers and chronic obstructive pulmonary disease patients: asthma and other

respiratory diseases.

Locations and Contacts

Agnaldo J Lopes, PhD, Phone: 55+(21) 98536162, Email: phel.lop@uol.com.br

Laboratory biomedical instrumentation - State University of Rio de Janeiro, Rio de Janeiro 20550013, Brazil; Recruiting
Gerusa M Costa, MSc, Principal Investigator
Additional Information


Starting date: June 2011
Last updated: January 31, 2012

Page last updated: August 23, 2015

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