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Migraine Inducing Effects and Changes in Brain Haemodynamics of PGI2

Information source: Glostrup University Hospital, Copenhagen
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Headache; Migraine; Vasodilatation

Intervention: Prostacyclin, PGI2 (Drug); Placebo (Drug)

Phase: N/A

Status: Recruiting

Sponsored by: Glostrup University Hospital, Copenhagen

Official(s) and/or principal investigator(s):
Troels Wienecke, MD, Principal Investigator, Affiliation: Danish Headache Center

Overall contact:
Troels Wienecke, MD, Phone: + 45 43 23 45 14, Email: trowie01@glo.regionh.dk

Summary

We hypothesised that intravenous infusion of PGI2 induced headache or migraine and cranial vasodilatation in migraineurs.

Clinical Details

Official title: Migraine Inducing Effects and Changes in Brain Haemodynamics of PGI2

Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double-Blind, Primary Purpose: Basic Science

Primary outcome: Headache and accompanying symptoms. Blood flow velocity in the middle cerebral artery, diameter changes in superficial temporal artery and radial artery.

Secondary outcome: Blood pressure, pulse

Eligibility

Minimum age: 18 Years. Maximum age: 55 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- migraine without aura and healthy apart from that

- age 18-55 years

- 50-100 kg

- Secure contraceptives

Exclusion Criteria:

- Tension Type Headache more than 3 time a month

- Other primary headaches

- Medication prior to the study (closer than 4 times plasma halflife)

- Migraine or headache 5 days prior to study.

- Hypertension (systolic BP >150 mmHg and/or diastolic BP >100 mmHg).

- Hypotension (systolic BP <90 mmHg and/or diastolic BP <50 mmHg).

- Heart-vessel disease of any kind incl cerebrovascular disease.

- Anamnestic or clinical signs of psychiatric disease or abuse.

- Anamnestic or clinical signs of disease of any kind relevant for participation in the

study.

Locations and Contacts

Troels Wienecke, MD, Phone: + 45 43 23 45 14, Email: trowie01@glo.regionh.dk

Danish Headache Center, Copenhagen, Glostrup DK-2600, Denmark; Recruiting
Troels Wienecke, MD, Principal Investigator
Additional Information

Starting date: December 2006
Last updated: July 30, 2007

Page last updated: August 23, 2015

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