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Assessment of Potential Interactions Between Methamphetamine and Selegiline - 1

Information source: National Institute on Drug Abuse (NIDA)
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Amphetamine-Related Disorders

Intervention: Selegiline (Drug)

Phase: Phase 1

Status: Active, not recruiting

Sponsored by: National Institute on Drug Abuse (NIDA)

Official(s) and/or principal investigator(s):
Thomas Newton, M.D., Principal Investigator, Affiliation: University of California, Los Angeles


The purpose of this study is to assess the potential interactions between intravenous methamphetamine and oral selegiline.

Clinical Details

Official title: Assessment of Potential Interactions Between Intravenous Methamphetamine and Oral Selegiline

Study design: Allocation: Randomized, Masking: Single Blind, Primary Purpose: Treatment

Primary outcome:

safety of selegiline

pharmacokinetic assessment

Detailed description: To determine the safety of the selegiline concurrent with d-methamphetamine challenges of 15mg & 30mg i. v. with the focus being on cardiovascular responses (HR,BP) to the i. v. methamphetamine challenges. This is a randomized, single-blind, placebo-controlled, two-arm study design to evaluate the safety of selegiline treatment, compared to placebo treatment, concurrent with i. v. methamphetamine challenges.


Minimum age: 18 Years. Maximum age: 45 Years. Gender(s): Both.


Inclusion Criteria:

- Volunteers who meet DSM-4 criteria for methamphetamine abuse or dependence;

non-treatment seeking individuals

- Be able to verbalize understanding of consent form; provide written informed consent

Exclusion Criteria:

- Please contact site for more information

Locations and Contacts

UCLA Integrated Substance Abuse Program, Los Angeles, California 90024, United States
Additional Information

Starting date: September 2001
Last updated: October 23, 2007

Page last updated: August 23, 2015

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