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Catheter Ablation Versus Medical Treatment of AF in Heart Failure

Information source: Barts & The London NHS Trust
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Atrial Fibrillation; Heart Failure

Intervention: Catheter ablation of persistent atrial fibrillation (Procedure); Medical treatment alone (Drug)

Phase: N/A

Status: Recruiting

Sponsored by: Barts & The London NHS Trust

Official(s) and/or principal investigator(s):
Richard J Schilling, MD FRCP, Principal Investigator, Affiliation: Professor of Cardiology, Barts & The London NHS Trust

Overall contact:
Ross J Hunter, MRCP, Phone: 442076018639, Email: ross.hunter@bartsandthelondon.nhs.uk

Summary

Heart failure and atrial fibrillation (AF) often coexist, and each increases the morbidity and mortality associated with the other. The investigators hypothesized that restoration of normal sinus rhythm by catheter ablation is superior to medical treatment of AF in heart failure. This study randomizes patients with heart failure and persistent AF to medical treatment of AF or catheter ablation to restore sinus rhythm.

Clinical Details

Official title: Catheter Ablation Versus Medical Treatment of AF in Heart Failure

Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Primary outcome: Difference in ejection fraction between groups

Secondary outcome:

Difference in peak VO2 between groups

Difference in NYHA class between groups

Difference in BNP between groups

Difference in Quality of Life between groups

Reduction in end systolic volume

Difference in heart failure symptoms

Eligibility

Minimum age: 18 Years. Maximum age: N/A. Gender(s): Both.

Criteria:

Inclusion Criteria:

- Persistent atrial fibrillation

- Symptomatic heart failure

Exclusion Criteria:

- Reversible causes of heart failure

- Contraindications to catheter ablation

Locations and Contacts

Ross J Hunter, MRCP, Phone: 442076018639, Email: ross.hunter@bartsandthelondon.nhs.uk

Barts & The London NHS Trust, London, UK EC1A 7BE, United Kingdom; Recruiting
Ross J Hunter, MRCP, Phone: 442076018639, Email: ross.hunter@bartsandthelondon.nhs.uk
Richard J Schilling, MD FRCP, Principal Investigator
Ross J Hunter, MRCP, Sub-Investigator
Additional Information

Starting date: March 2005
Last updated: August 5, 2011

Page last updated: August 23, 2015

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