Catheter Ablation Versus Medical Treatment of AF in Heart Failure
Information source: Barts & The London NHS Trust
ClinicalTrials.gov processed this data on August 23, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Atrial Fibrillation; Heart Failure
Intervention: Catheter ablation of persistent atrial fibrillation (Procedure); Medical treatment alone (Drug)
Phase: N/A
Status: Recruiting
Sponsored by: Barts & The London NHS Trust Official(s) and/or principal investigator(s): Richard J Schilling, MD FRCP, Principal Investigator, Affiliation: Professor of Cardiology, Barts & The London NHS Trust
Overall contact: Ross J Hunter, MRCP, Phone: 442076018639, Email: ross.hunter@bartsandthelondon.nhs.uk
Summary
Heart failure and atrial fibrillation (AF) often coexist, and each increases the morbidity
and mortality associated with the other. The investigators hypothesized that restoration of
normal sinus rhythm by catheter ablation is superior to medical treatment of AF in heart
failure. This study randomizes patients with heart failure and persistent AF to medical
treatment of AF or catheter ablation to restore sinus rhythm.
Clinical Details
Official title: Catheter Ablation Versus Medical Treatment of AF in Heart Failure
Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
Primary outcome: Difference in ejection fraction between groups
Secondary outcome: Difference in peak VO2 between groupsDifference in NYHA class between groups Difference in BNP between groups Difference in Quality of Life between groups Reduction in end systolic volume Difference in heart failure symptoms
Eligibility
Minimum age: 18 Years.
Maximum age: N/A.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- Persistent atrial fibrillation
- Symptomatic heart failure
Exclusion Criteria:
- Reversible causes of heart failure
- Contraindications to catheter ablation
Locations and Contacts
Ross J Hunter, MRCP, Phone: 442076018639, Email: ross.hunter@bartsandthelondon.nhs.uk
Barts & The London NHS Trust, London, UK EC1A 7BE, United Kingdom; Recruiting Ross J Hunter, MRCP, Phone: 442076018639, Email: ross.hunter@bartsandthelondon.nhs.uk Richard J Schilling, MD FRCP, Principal Investigator Ross J Hunter, MRCP, Sub-Investigator
Additional Information
Starting date: March 2005
Last updated: August 5, 2011
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