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Treatment of Early Nasal Polyposis With Topical Triamcinolone

Information source: Steward St. Elizabeth's Medical Center of Boston, Inc.
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Nasal Polyps

Intervention: Triamcinolone (Drug); Triamcinolone (Drug)

Phase: Phase 2

Status: Terminated

Sponsored by: Steward St. Elizabeth's Medical Center of Boston, Inc.

Official(s) and/or principal investigator(s):
Peter Catalano, MD, Study Director, Affiliation: Steward St. Elizabeth's Medical Center of Boston, Inc.

Summary

The purpose of this study is to compare the effectiveness of intranasal Triamcinolone delivered through a bio-absorbable nasal dressing verses oral steroids and a saline soaked dressing, in the treatment and prevention of early nasal polyposis.

Clinical Details

Official title: Treatment of Early Nasal Polyposis With Topical Triamcinolone

Study design: Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Primary outcome: To evaluate the efficacy of a Nasopore dressing soaked in Triamcinolone verses oral steroids and a saline soaked sponge

Detailed description: Nasopore, a bio-absorbable nasal dressing, may offer an alternative route of sustained steroid drug delivery. The use of topical targeted intranasal steroids may prevent the routine adverse effects of oral steroids while maintaining the same therapeutic / clinical efficacy.

Eligibility

Minimum age: 18 Years. Maximum age: N/A. Gender(s): Both.

Criteria:

Inclusion Criteria:

- Age > 18 years

- Patients with early nasal polyposis

Exclusion Criteria:

- Age < 18 years

- Patients with active sinus infections

- Patients on long term steroids

- Allergy or sensitivity to steroids

- Patients with Antrochoanal polyps

- Patients who received topical steroids by bio-resorbable sponge or oral steroids

Locations and Contacts

St. Elizabeth's Medical Center, 736 Cambridge St, Brighton, Massachusetts 02135, United States
Additional Information

Starting date: July 2010
Last updated: January 2, 2014

Page last updated: August 23, 2015

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