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The Use of Propranolol to Block Memory Reconsolidation in PTSD

Information source: Wayne State University
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Posttraumatic Stress Disorders

Intervention: Propranolol (Drug); Placebo (Drug)

Phase: Phase 2

Status: Terminated

Sponsored by: Wayne State University

Official(s) and/or principal investigator(s):
Deane Aikins, PhD, Principal Investigator, Affiliation: Wayne State University


The purpose of this investigation is to see if propranolol will reduce the psychophysiological hyperactivation associated with memories of combat stress in Veterans with Posttraumatic Stress Disorder.

Clinical Details

Official title: The Use of Propranolol to Block Memory Reconsolidation in Post Traumatic Stress Disorders (PTSD)

Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Primary outcome: Facial corrugator EMG

Secondary outcome:

CAPS score

PCL-M score

Detailed description: The goal of this translational research project is to generate a pilot sample of data from an investigation of a novel therapeutic approach to post traumatic stress disorder (PTSD). Current treatments for PTSD include exposure and other aspects of cognitive therapy as well as drug therapies based on serotonin-reuptake inhibiting antidepressant agents. However, these treatments are often unsuccessful, and symptoms in affected individuals may persist for decades. The central hypothesis guiding this research project posits that acquired fear responses, such as those in PTSD, when reactivated by recall become sensitive to noradrenergic modulation and thus may be permanently attenuated by blocking noradrenergic transmission. Further, we predict that this attenuation will facilitate subsequent therapy. In the current study, we will be investigating this model in three groups of Veterans of either Operation Iraqi Freedom or Operation Enduring Freedom (OIF/OEF) with PTSD: 1) Individuals who receive propranolol following recall of a traumatic memory (Propranolol-trauma); 2) Individuals who receive a placebo following recall of a traumatic memory (Placebo-trauma), and; 3) Individuals who receive propranolol following recall of an affective neutral memory (Propranolol-neutral). In addition, traumatic memory recall will be psychophysiologically assessed by measuring Veterans' facial corrugator electromyography (EMG), skin conductance, blood pressure and cardiovascular inter-beat interval responses pre- and one month post-medication administration.


Minimum age: 18 Years. Maximum age: 45 Years. Gender(s): Female.


Inclusion Criteria:

- Participants will meet the clinical criteria of PTSD (DSM IVTR) secondary to combat

exposure. Exclusion Criteria:

- Current illicit substance use or alcohol consumption, as determined by urine

toxicology and alcohol breath test.

- Any diagnosis of current comorbid psychotic disorders, bipolar disorder, or illicit

substance or alcohol abuse or dependence.

- Any current prescription medication usage or supplement (dietary or herbal) usage

that is contraindicated with propranolol.

- Active enrollment into any psychiatric or psychological treatment.

- Any condition that contraindicates the use of propranolol, such as:

- history of bronchial asthma.

- heart block.

- sinus bradycardia.

- congestive heart failure.

- insulin-dependent diabetes.

- initial systolic blood pressure < 100 mmHg.

- Hyperthyroidism.

- Thyroid disease.

- Renal or liver impairment.

Locations and Contacts

John D Dingell VA Hospital, Detroit, Michigan 48201, United States
Additional Information

Starting date: September 2007
Last updated: August 14, 2015

Page last updated: August 23, 2015

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