The Effect of Glyceryl Trinitate and Diamox on Cerebral Haemodynamics.
Information source: Danish Headache Center
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Migraine
Intervention: GTN, Diamox (Drug)
Phase: N/A
Status: Not yet recruiting
Sponsored by: Danish Headache Center Official(s) and/or principal investigator(s):
Messoud Ashina, MD,Ph.D, Study Chair, Affiliation: Danish Headache Center
Overall contact:
Mohammad Sohail Asghar, MD, Phone: +4543232161, Email: asgsoh01@glostruphosp.kbhamt.dk
Summary
After infusion / injection of Glyceryl trinitrate and Diamox it is wished to study the
effect of drugs on the cerebral haemodynamics such as Cerebral blod flow and cerebral blod
volume.
Clinical Details
Official title: The Effect of Glyceryl Trinitrate (GTN) and Diamox on Cerebral Haemodynamics Judged With the Help of 3-Tesla MRI.
Study design: Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Double-Blind, Primary Purpose: Educational/Counseling/Training
Detailed description:
Experimental headache model open a unike opportunity to study the pathophysiological
mechanisms behind headache in general and migrane in particular. Previous studies have used
various techniques to study the cerebral haemodynamics as a basis for the headache
pathophysiology. We wish to use a 3-Tesa MRI so study the cerebral haemodynamics after
application of various pharmacological substances.
The most used experimental headache model is the glyceryl trinitrate model (GTN). Where
infusion of the NO donor GTN induces headache and changes in the cerebral arteries. On the
other hand injection of Diamox (Acetazolamide) apparently causes increase of the cerebral
blod flow with out dilation of the arteries. We wish to study the precise effect of GTN and
diamox on the cerebral haemodynamics such as Cerebral blod flow (CBF) and Cerebral blod
volume (CBV) via a 3-Tesla MRI.
Eligibility
Minimum age: 18 Years.
Maximum age: 55 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- healthy volunteers; men and women age 18-50 years.
- weight 50-100 kg
Exclusion Criteria:
- Tension type headache more then once per month during the last year.
- Other primary headache types.
- Daily use of medication.
- Pregnant or lactating women.
- Headache on the trail day or 24 hours prior to the trial.
- Contraindications to MRI.
- Hypotension og hypertension.
- Other significant medical conditions judged by the doctor in charge.
Locations and Contacts
Mohammad Sohail Asghar, MD, Phone: +4543232161, Email: asgsoh01@glostruphosp.kbhamt.dk
Danish Headache Center, Neurological Dep. Glostrup hospital, Glostrup 2770, Denmark
Additional Information
Starting date: August 2006
Last updated: August 14, 2006
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