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The Efficacy of Isocapnic Hyperpnoea to Accelerate Recovery After General Anesthesia With Sevoflurane

Information source: University Health Network, Toronto
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Anesthesia

Intervention: Isocapnic Hyperponea (Procedure)

Phase: Phase 3

Status: Completed

Sponsored by: University Health Network, Toronto

Official(s) and/or principal investigator(s):
Rita Katznelson, MD, Principal Investigator, Affiliation: Toronto General Hospital, University Health Network

Summary

The twilight phase between being asleep and awake during recovery from anesthesia is a precarious time fraught with risks to the post-operative patient. Hyperventilation accelerates the elimination of inhaled anesthetics but reduces their CO2 blood concentrations which delays their resumption of spontaneous breathing. We previously showed that our method of hyperventilation without affecting the CO2 concentration--which we call IH--accelerates the rate of emergence from anesthesia with isoflurane. In this study we will study the effect of IH on the rate of emergence from Sevoflurane anesthesia.

Clinical Details

Official title: The Efficacy of Isocapnic Hyperpnoea to Accelerate Recovery After General Anesthesia With Sevoflurane.

Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind, Primary Purpose: Treatment

Primary outcome: Time to recovery from anesthesia as indicated by time to extubation and rate of change of BIS score

Secondary outcome: Quality of recovery in the recovery room as indicated by the level of consciousness, incidence of nausea, vomiting, shivering and other phenomena occuring during recovery

Eligibility

Minimum age: 18 Years. Maximum age: 80 Years. Gender(s): Female.

Criteria:

Inclusion criteria: 1. Elective gynecological procedure 2. ASA I-III 3. Age 18-80 years 4. Signed informed consent Exclusion criteria: 1. ASA IV 2. Patients with contra-indications to Sevoflurane anesthesia or other anesthetics included in the protocol 3. Active smoking, asthma or other history of hyper-reactive airway disease 4. History of chronic obstructive lung disease limiting exercise 5. History of angina, previous myocardial infarction, valvular heart disease, or heart surgery 6. Presence of heart murmurs or neck bruits 7. ECT abnormalities including atrial fibrillation, prolonged P-R interval, prolonged Q-T interval, presence of Q waves in inferior, anterior or lateral leads, criteria for left ventricular hypertrophy, T-wave abnormalities, 8. History of difficult airway access 9. Pulmonary hypertension and/or right ventricle dysfunction 10. History of bulous emphysema, and/or spontaneous pneumothorax 11. History of alcohol or drugs abuse 12. Known history of psychiatric illness and/or medications 13. Patients that required postoperative mechanical ventilation for any reason

Locations and Contacts

Toronto General Hospital, University Health Network, Toronto, Ontario M5G 2C4, Canada
Additional Information

Starting date: October 2005
Last updated: August 3, 2010

Page last updated: August 23, 2015

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