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Penicillin and Metronidazole in Treatment of Peritonsillar Abscess

Information source: Helsinki University Central Hospital
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Peritonsillar Abscess

Intervention: penicillin and metronidazole in peritonsillar abscess (Drug)

Phase: N/A

Status: Completed

Sponsored by: Helsinki University Central Hospital

Official(s) and/or principal investigator(s):
Karin V Blomgren, MD, PhD, Principal Investigator, Affiliation: consultant


Treatment of peritonsillar abscess varies. To study whether broad spectrum antibiotics are required in addition to abscess drainage we perform a prospective, double blind, placebo-controlled, randomised study on 200 adult patients with peritonsillar abscess. 100 patients are given penicillin and metronidazole and 100 patients get penicillin and placebo. Recovery and recurrence and analyzed.

Clinical Details

Official title: Penicillin and Metronidazole in Treatment of Peritonsillar Abscess - Prospective, Double-blind, Randomized, Placebo-controlled Study

Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator), Primary Purpose: Treatment

Primary outcome: Efficacy of metronidazole in addition to penicillin in preventing the recurrence of peritonsillar abscess

Secondary outcome: Does metronidazole in addition to penicillin enhance the recovery of peritonsillar abscess


Minimum age: 18 Years. Maximum age: N/A. Gender(s): Both.


Inclusion Criteria:

- referring doctor suspects peritonsillar abscess

- patient is voluntary

- patient has daily access to his/her e-mail

- patient speaks and understands Finnish of Swedish

- female patients have adequate birth-control method

- patient has peritonsillar abscess

Exclusion Criteria:

- allergy to penicillin

- allergy to metronidazole

- use of metronidazole in preceding one month

- pregnancy

- breast-feeding

- renal insufficiency

- liver insufficiency

- alcoholism (drunk at least once a week)

- participant in another clinical trial at the moment

- treatment of peritonsillar abscess requires in-patient care

- tonsillectomy during the next 30 days

- army recruit

Locations and Contacts

Helsinki University Central Hospital, Helsinki 00029, Finland
Additional Information

Starting date: February 2010
Last updated: April 8, 2011

Page last updated: August 23, 2015

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