Effects of Hydrocortisone and D-Cycloserine on Fear Extinction in Veterans With Posttraumatic Stress Disorder
Information source: Department of Veterans Affairs
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Stress Disorders, Posttraumatic
Intervention: Hydrocortisone (Drug); D-Cycloserine (Drug); Placebo (Drug)
Phase: N/A
Status: Recruiting
Sponsored by: Department of Veterans Affairs Official(s) and/or principal investigator(s):
Sabra S. Inslicht, PhD, Principal Investigator, Affiliation: San Francisco VA Medical Center, San Francisco, CA
Overall contact:
Sabra S Inslicht, PhD, Phone: (415) 221-4810, Ext: 3341, Email: sabra.inslicht@va.gov
Summary
This is a research study examining the use of two medications, Hydrocortisone and
D-Cycloserine, compared to an inactive substance (placebo), on their ability to reduce fear
responses and memory of fear in veterans with symptoms of Posttraumatic Stress Disorder
(PTSD). These responses will be tested using a fear learning and memory task administered by
computer.
Clinical Details
Official title: Effects of Hydrocortisone and D-Cycloserine on Fear Extinction in Veterans With Posttraumatic Stress Disorder
Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Factorial Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Basic Science
Primary outcome: Skin Conductance
Secondary outcome: Heart RateEye Blink
Eligibility
Minimum age: 18 Years.
Maximum age: 65 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- Veterans and civilians with an age range of 18 to 65 years
- Participants must be physically healthy volunteers
Exclusion Criteria:
- Individuals who fall outside the age range
- Individuals with medical conditions that would interfere with participation
- Other criteria
Locations and Contacts
Sabra S Inslicht, PhD, Phone: (415) 221-4810, Ext: 3341, Email: sabra.inslicht@va.gov
San Francisco VA Medical Center, San Francisco, CA, San Francisco, California 94121, United States; Recruiting
Sabra S Inslicht, PhD, Phone: 415-221-4810, Ext: 3341, Email: sabra.inslicht@va.gov
Charles R. Marmar, MD, Sub-Investigator
Sabra S. Inslicht, PhD, Principal Investigator
Additional Information
Starting date: July 2008
Last updated: April 29, 2015
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