Varenicline Effects In Schizophrenic Smokers
Information source: Nathan Kline Institute for Psychiatric Research
ClinicalTrials.gov processed this data on August 23, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Schizophrenia; Tobocco Use Disorder; Nicotine Dependance
Intervention: Varenicline (Drug)
Phase: Phase 4
Status: Completed
Sponsored by: Nathan Kline Institute for Psychiatric Research Official(s) and/or principal investigator(s): Robert C Smith, MD, PhD, Principal Investigator, Affiliation: Nathan Kline insitutue fo Psychiatric Research; NYU School of Medicine
Summary
This is an open label pre-post study of the effects of clinical treatment with varenicline
on 1) decreasing smoking in schizophrenic patients, 2) improving selected cognitive measures
in schizophrenic patients, and 3) effects nicotinic binding to leukocytes and DNMT1 mRNA in
lymphocytes. Patients are assessed on subjective and objective measures of smoking ,
selected cognitive measures, and special chemical measures, during baseline testing and
during 8 weeks of treatment with varenicline ( 1-3 mg/day).
Clinical Details
Official title: Evaluation of Varenicline's Clinical Efficacy for Continued Smoking Abstinence When Used in the Clinical Treatment of Schizophrenic Patients Hospitalized in an Institution With a Ban on Cigarette Smoking
Study design: Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
Primary outcome: self report of smokingCO breathalyzer level plasma nicotine and cotinine
Secondary outcome: RBANS neuropsychological batteryHuman Analogue of computer water maze task
Eligibility
Minimum age: 18 Years.
Maximum age: 65 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- Clinical Diagnosis of Schizophrenia or Schizoaffective Psychosis
- Recent History of Cigarette smoking
- Ages 18-65
Locations and Contacts
Manhattan Psychatirc Center, New York City, New York 10035, United States
Additional Information
Starting date: June 2007
Last updated: May 17, 2012
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