Prospective Randomized Comparison of Zymar(Gatifloxacin) and Vigamox (Moxifloxacin) in Killing Conjunctival Bacterial Flora Following a One-hour Application
Information source: Stanford University
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Conjunctical Flora
Intervention: gatifloxacin, moxifloxacin (Drug)
Phase: N/A
Status: Withdrawn
Sponsored by: Stanford University Official(s) and/or principal investigator(s):
Christopher Ta, MD, Principal Investigator, Affiliation: Stanford University
Summary
Topical ophthalmic antibiotics are common prescribed just prior to eye surgery to lower the
risk of infection. Previous studies have suggested that antibiotics containing a
preservative (Zymar) kill bacteria much quicker than those without a preservative (Vigamox).
The purpose of this research is to compare how quickly to the two commonly prescribed
antibiotics eliminate bacteria from the eye surface.
Clinical Details
Official title: Prospective Randomized Comparison of Zymar(Gatifloxacin) and Vigamox (Moxifloxacin) in Killing Conjunctival Bacterial Flora Following a One-hour
Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Factorial Assignment, Masking: Single Blind, Primary Purpose: Prevention
Primary outcome: Antibiotic killing of conjunctival bacterial flora 1 hour after application
Eligibility
Minimum age: 50 Years.
Maximum age: N/A.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- Age- older than 50 years of age
- Diagnosis- Cataract or had cataract surgery
Exclusion Criteria:
- Systemic or topical antibiotic treatment within 30 days
- Use of systemic or topical steroids
- Active ocular infection
- Ocular surgery in the past 6 months
- Allergy to fluoroquinolones
Locations and Contacts
Additional Information
Related publications: Ta CN, He L, Nguyen E, De Kaspar HM. Prospective randomized study determining whether a 3-day application of ofloxacin results in the selection of fluoroquinolone-resistant coagulase-negative Staphylococcus. Eur J Ophthalmol. 2006 May-Jun;16(3):359-64. Miño de Kaspar H, Koss MJ, He L, Blumenkranz MS, Ta CN. Antibiotic susceptibility of preoperative normal conjunctival bacteria. Am J Ophthalmol. 2005 Apr;139(4):730-3. de Kaspar HM, Kreidl KO, Singh K, Ta CN. Comparison of preoperative conjunctival bacterial flora in patients undergoing glaucoma or cataract surgery. J Glaucoma. 2004 Dec;13(6):507-9. Ta CN, Chang RT, Singh K, Egbert PR, Shriver EM, Blumenkranz MS, Miño de Kaspar H. Antibiotic resistance patterns of ocular bacterial flora: a prospective study of patients undergoing anterior segment surgery. Ophthalmology. 2003 Oct;110(10):1946-51. Ta CN, Egbert PR, Singh K, Shriver EM, Blumenkranz MS, Miño De Kaspar H. Prospective randomized comparison of 3-day versus 1-hour preoperative ofloxacin prophylaxis for cataract surgery. Ophthalmology. 2002 Nov;109(11):2036-40; discussion 2040-1.
Starting date: April 2007
Last updated: June 12, 2013
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