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CBT With Disulfiram and Contingency Management

Information source: Yale University
ClinicalTrials.gov processed this data on August 20, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Cocaine Abuse

Intervention: disulfiram (Drug); Placebo (Drug); Placebo plus Contingency Management (Behavioral); Disulfiram plus Contingency Management (Drug)

Phase: Phase 1

Status: Completed

Sponsored by: Yale University

Official(s) and/or principal investigator(s):
Kathleen M. Carroll, PhD, Principal Investigator, Affiliation: Yale School of Medicine

Summary

This is a study of four treatments for chronic cocaine use and may help study participants to control their drug use. All participants will receive weekly individual cognitive behavioral therapy (CBT).

Clinical Details

Official title: Maximizing the Efficacy of Cognitive Behavioral Therapy With Medication and Contingency Management

Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Factorial Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment

Primary outcome:

Change in Cocaine Use by Self Report

Change in Cocaine Use by Urine Toxicology Results

Detailed description: This study will compare four types of treatment involving skills training and incentives for attending sessions or taking study medication. Disulfiram is a widely prescribed deterrent to alcohol use. In addition to weekly cognitive behavioral therapy (CBT), participants will be assigned to one of the following treatments: 1. placebo 2. disulfiram 3. placebo plus incentives for cocaine abstinence and medication compliance (prize CM) 4. disulfiram plus incentives for cocaine abstinence and medication compliance

Eligibility

Minimum age: 18 Years. Maximum age: 50 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- 18-50 year old

- cocaine dependent

- willing to sign consent

- willing to accept randomization to intervention

Exclusion Criteria:

- significant medical conditions

- psychiatric disorder with current use of prescribed psychotropic medication

- lifetime schizophrenia or bipolar disorder

- suicidality or homicidality

- unlikely to be able to complete 1 year follow up

- unable to speak or read English at a third grade level

Locations and Contacts

APT Foundation, New Haven, Connecticut 06510, United States
Additional Information

Starting date: April 2005
Last updated: November 26, 2014

Page last updated: August 20, 2015

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