CBT With Disulfiram and Contingency Management
Information source: Yale University
ClinicalTrials.gov processed this data on August 20, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Cocaine Abuse
Intervention: disulfiram (Drug); Placebo (Drug); Placebo plus Contingency Management (Behavioral); Disulfiram plus Contingency Management (Drug)
Phase: Phase 1
Status: Completed
Sponsored by: Yale University Official(s) and/or principal investigator(s): Kathleen M. Carroll, PhD, Principal Investigator, Affiliation: Yale School of Medicine
Summary
This is a study of four treatments for chronic cocaine use and may help study participants
to control their drug use. All participants will receive weekly individual cognitive
behavioral therapy (CBT).
Clinical Details
Official title: Maximizing the Efficacy of Cognitive Behavioral Therapy With Medication and Contingency Management
Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Factorial Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment
Primary outcome: Change in Cocaine Use by Self ReportChange in Cocaine Use by Urine Toxicology Results
Detailed description:
This study will compare four types of treatment involving skills training and incentives for
attending sessions or taking study medication. Disulfiram is a widely prescribed deterrent
to alcohol use. In addition to weekly cognitive behavioral therapy (CBT), participants will
be assigned to one of the following treatments:
1. placebo
2. disulfiram
3. placebo plus incentives for cocaine abstinence and medication compliance (prize CM)
4. disulfiram plus incentives for cocaine abstinence and medication compliance
Eligibility
Minimum age: 18 Years.
Maximum age: 50 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- 18-50 year old
- cocaine dependent
- willing to sign consent
- willing to accept randomization to intervention
Exclusion Criteria:
- significant medical conditions
- psychiatric disorder with current use of prescribed psychotropic medication
- lifetime schizophrenia or bipolar disorder
- suicidality or homicidality
- unlikely to be able to complete 1 year follow up
- unable to speak or read English at a third grade level
Locations and Contacts
APT Foundation, New Haven, Connecticut 06510, United States
Additional Information
Starting date: April 2005
Last updated: November 26, 2014
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