Treatment of Orthostatic Intolerance
Information source: Vanderbilt University
Information obtained from ClinicalTrials.gov on October 19, 2009
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Tachycardia; Chronic Orthostatic Intolerance
Intervention: Acetazolamide (Drug); Atomoxetine (Drug); Baseline (No Drug) (Other); Clonidine (Drug); Entacapone (Drug); Entacapone & Propranolol (Drug); Atomoxetine & Propranolol (Drug); Indomethacin (Drug); Mecamylamine (Drug); Isosorbide Dinitrate (Drug); Melatonin (Dietary Supplement); Midodrine (Drug); Modafinil (Drug); Octreotide (Drug); Placebo (Radiation); Propranolol (Drug); Modafinil & Propranolol (Drug); Sertraline (Drug); IV Saline (Procedure); Drinking Water (Other); Breathing Device (Device); memantine (Drug)
Phase: Phase 1/Phase 2
Status: Recruiting
Sponsored by: Vanderbilt University Official(s) and/or principal investigator(s):
Satish R Raj, MD MSCI, Principal Investigator, Affiliation: Vanderbilt University School of Medicine
Overall contact:
Bonnie K Black, RN NP, Email: adcresearch@vanderbilt.edu
Summary
This trial is designed to study the effects of various mechanistically unique medications in
controlling excessive increases in heart rate with standing and in improving the symptoms of
orthostatic intolerance in patients with this disorder.
Clinical Details
Official title: Treatment of Orthostatic Intolerance
Study design: Treatment, Non-Randomized, Single Blind (Subject), Placebo Control, Crossover Assignment, Safety/Efficacy Study
Primary outcome: Increase in heart rate with standing
Secondary outcome: Sitting heart rateStanding heart rate Blood pressure Decrease in blood pressure with standing Orthostatic symptoms score
Eligibility
Minimum age: 18 Years.
Maximum age: 70 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- Chronic symptoms (> 6 months) with standing upright
Exclusion Criteria:
- Obvious cause of hypovolemia or drugs that could worsen tachycardia
- Chronic severe medical conditions such as cancer or ischemic heart disease
Locations and Contacts
Bonnie K Black, RN NP, Email: adcresearch@vanderbilt.edu
Vanderbilt University Autonomic Dysfunction Center, Nashville, Tennessee 37232-2195, United States; Recruiting
Additional Information
Vanderbilt University Autonomic Dysfunction Center website
Starting date: April 1997
Last updated: June 23, 2009
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