DrugLib.com — Drug Information Portal

Rx drug information, pharmaceutical research, clinical trials, news, and more



Dexamethasone in Lower Third Molar Surgery

Information source: University of Belgrade
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Impacted Third Molar Tooth

Intervention: Intramuscular application (Procedure); Submucosal application (Procedure); 4mg Dexamethasone submucosal (Drug); 8mg Dexamethasone submucosal (Drug); 4mg Dexamethasone preoperative (Procedure); 4mg Dexamethasone postoperative (Procedure)

Phase: Phase 4

Status: Recruiting

Sponsored by: University of Belgrade

Official(s) and/or principal investigator(s):
Miroslav M Andric, DDS, PhD, Principal Investigator, Affiliation: School of Dental Medicine

Overall contact:
Miroslav M Andric, DDS, PhD, Phone: 00381112685864, Ext: 244, Email: miroslav.andric@stomf.bg.ac.rs

Summary

The aim of this randomized double-blind cross over clinical trial is to investigate effectiveness of different routes of applications (intramuscular and submucous at the site of surgery) and doses (4 mg and 8 mg) of Dexamethasone on swelling, trismus, pain and quality of life after lower third molar surgery.

Clinical Details

Official title: Effectiveness of Different Application Modalities of Dexamethasone on Clinical Parameters and Quality of Life After Lower Third Molar Surgery

Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Primary outcome: Facial swelling (using 3 facial measurements (in millimeters)

Secondary outcome:

Postoperative pain (visual analog scale)

Postoperative trismus (difference in interincisal distance at the maximal mouth opening (in millimeters) before and after surgery)

Postoperative discomfort (25-items custom made questionnaire)

Eligibility

Minimum age: 18 Years. Maximum age: 65 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- Healthy patients (ASA I)

- Bilateral symmetrically impacted lower third molars according to Pel-Gregory's and

Winter's classification Exclusion Criteria:

- Heavy tobacco smokers

- Drug and / or alcohol abusers

Locations and Contacts

Miroslav M Andric, DDS, PhD, Phone: 00381112685864, Ext: 244, Email: miroslav.andric@stomf.bg.ac.rs

School of Dental Medicine, Belgrade 11000, Serbia; Recruiting
Miroslav M Andric, DDS, PhD
Vladimir S Todorovic, DDS, MSc, Principal Investigator
Aleksandar S Jakovljevic, DDS, Sub-Investigator
Miroslav R Vasovic, DDS, Sub-Investigator
Additional Information

Starting date: January 2014
Last updated: April 14, 2015

Page last updated: August 23, 2015

-- advertisement -- The American Red Cross
 
Home | About Us | Contact Us | Site usage policy | Privacy policy

All Rights reserved - Copyright DrugLib.com, 2006-2017