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Impedance Cardiographic (ICG) Assessment of Pregnant Women With Severe Hypertension to Assess Impact of Standard Therapy

Information source: University of Mississippi Medical Center
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Pregnancy; Proteinuria, With Hypertension (Severe Pre-eclampsia); Delivery; Proteinuria, With Gestational Hypertension (Pre-eclampsia, Severe); Pregnancy; Hypertension, Gestational Hypertension, With Albuminuria (Severe Pre-eclampsia)

Phase: N/A

Status: Completed

Sponsored by: University of Mississippi Medical Center

Official(s) and/or principal investigator(s):
James N Martin, MD, Principal Investigator, Affiliation: SOM-Obstetrics & Gynecology


The utilization of external cardiohemodynamic patient assessment, applying non-invasive stick-on contact patches to the mother's neck on either side and chest wall on either side, enables the practitioner to have information about the patient's cardiac function and vascular status beyond simply blood pressure and pulse. This information, once collected, should open the practitioner's eyes to better assess the patient's disease status and her response to therapy. We will use this information to compare the effectiveness of the two standard medications used for treatment of maternal high blood pressure.

Clinical Details

Official title: Impedance Cardiographic Assessment of Gravidas With Severe Hypertension (ICASH)to Assess Impact of Standard Therapy on Hemodynamic Parameters - A Pilot Study

Study design: Time Perspective: Prospective

Primary outcome: Usefulness of Impedance Cardiography (ICG) in pregnant women with hypertension

Detailed description: Pregnant patients with severe acute hypertension due either to superimposed preeclampsia, severe preeclampsia or severe gestational hypertension will be randomized to receive either of two antihypertensive agents (hydralazine or labetalol). Just before drug administration and immediately thereafter impedance cardiography of the patient will be undertaken and the results analyzed relative to the cardiac profile and the drug administered to reduce the severe hypertension.


Minimum age: 18 Years. Maximum age: 45 Years. Gender(s): Female.


Inclusion Criteria:

- Nulliparous or parous patients with severe hypertension

- Singleton gestation

- Gestational age greater than 20 weeks

Exclusion Criteria:

- Multiple gestation

- Gestational age less than 20 weeks

Locations and Contacts

Wiser Hospital for Women and Infants at the University of Mississippi Medical Center, Jackson, Mississippi 39216, United States
Additional Information

Starting date: December 2009
Last updated: December 11, 2013

Page last updated: August 23, 2015

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