This randomized, parallel-group, placebo-controlled, multicenter study will evaluate the
reduction in disease activity and the safety of tocilizumab (RoActemra/Actemra) in
combination with traditional disease-modifying anti-rheumatic drugs (DMARDs) in patients
with active, moderate to severe rheumatoid arthritis. In the double-blind part of the study,
patients will be randomized to receive either 162 mg tocilizumab or placebo subcutaneously
every 2 weeks for 24 weeks using a pre-filled syringe. In the open-label part of the study,
patients will be randomized to receive 162 mg tocilizumab subcutaneously every 2 weeks from
Week 24 to Week 96 using a pre-filled syringe or an auto-injector.
Minimum age: 18 Years.
Maximum age: N/A.
Gender(s): Both.
Buenos Aires C1015ABO, Argentina
Córdoba 5000, Argentina
San Miguel de Tucuman 4000, Argentina
Cairns 4870, Australia
Kogarah 2217, Australia
Curitiba 80060-240, Brazil
Goiania 74043-011, Brazil
Juiz de Fora 36010-570, Brazil
Porto Alegre 90610-000, Brazil
Porto Alegre 91350-200, Brazil
Rio de Janeiro 22271-100, Brazil
Salvador 40050-410, Brazil
Sao Paulo 04266-010, Brazil
Sao Paulo 05437-010, Brazil
Sao Paulo 5403900, Brazil
São Paulo 04026-000, Brazil
São Paulo 1244030, Brazil
Vitoria 29055-450, Brazil
Plovdiv 4002, Bulgaria
Plovdiv 4003, Bulgaria
Sofia 1612, Bulgaria
Sofia 2233, Bulgaria
Varna 9010, Bulgaria
Bogota, Colombia
Chia-cundinamarca, Colombia
Medellin, Colombia
Athens 11527, Greece
Athens 15121, Greece
Thessaloniki 54636, Greece
Guatemala City 01010, Guatemala
Guatemala City 01013, Guatemala
Guatemala City 01015, Guatemala
Budapest 1036, Hungary
Debrecen 4004, Hungary
Ashkelon 78306, Israel
Beer Sheva 84101, Israel
Haifa 31048, Israel
Haifa 31096, Israel
Ramat Gan 52621, Israel
Rishon Lezion, Israel
Tel Aviv 64239, Israel
Batu Caves 68100, Malaysia
Kota Kinabalu 88586, Malaysia
Kuala Lumpur 50603, Malaysia
Chihuahua 31000, Mexico
Culiacan 80000, Mexico
Guadalajara 44158, Mexico
Leon 37320, Mexico
Merida 97000, Mexico
Mexicali 21100, Mexico
Mexico 44620, Mexico
Morelia 58070, Mexico
Obregon 85000, Mexico
Queretaro 76000, Mexico
Queretaro 76178, Mexico
Otahuhu 1006, New Zealand
Panama City 32400, Panama
Cebu 6000, Philippines
Davao 8006, Philippines
Manila 1780, Philippines
Bytom 41902, Poland
Dzialdowo 13-200, Poland
Elblag 82-300, Poland
Koscian 64-000, Poland
Krakow 31-121, Poland
Torun 87-100, Poland
Warszawa 02-653, Poland
Kemerovo 650099, Russian Federation
Moscow 115522, Russian Federation
Moscow 117049, Russian Federation
Moscow 129327, Russian Federation
Novosibirsk 630099, Russian Federation
Petrozavodsk 185019, Russian Federation
Ryazan 390026, Russian Federation
Saint-petersburg 197341, Russian Federation
St Petersburg 197022, Russian Federation
St Petersburg 190068, Russian Federation
UFA 450005, Russian Federation
Voronezh 394066, Russian Federation
Durban 4013, South Africa
Pinelands 7405, South Africa
Pretoria 0002, South Africa
La Coruna 15006, Spain
Oviedo 33006, Spain
Sevilla 41009, Spain
Fribourg 1708, Switzerland
Genève 1211, Switzerland
Lausanne 1011, Switzerland
Zürich 8063, Switzerland
Bangkok 10400, Thailand
Bangkok 10700, Thailand
Calgary, Alberta T2N 2T9, Canada
Peoria, Arizona 85381, United States
Scottsdale, Arizona 85258, United States
Tucson, Arizona 85723, United States
Tucson, Arizona 85724, United States
Fullerton, California 92835, United States
San Diego, California 92108, United States
San Leandro, California 94578, United States
West Hills, California 91307, United States
Trumbull, Connecticut 06611, United States
Boca Raton, Florida 33486, United States
Jupiter, Florida 33458, United States
Ormond Beach, Florida 32174, United States
Sarasota, Florida 34292, United States
Gainesville, Georgia 30501, United States
Idaho Falls, Idaho 83404, United States
Meridan, Idaho 83642, United States
Springfield, Illinois 62704, United States
Vernon Hills, Illinois 60061, United States
Winnipeg, Manitoba R3A 1M3, Canada
Winnipeg, Manitoba R3N 0K6, Canada
Crofton, Maryland 21114, United States
Hagerstown, Maryland 21740, United States
Wheaton, Maryland 20902, United States
Flowood, Mississippi 39232, United States
Jackson, Mississippi 39202, United States
Saint Louis, Missouri 63128, United States
St Louis, Missouri 63141, United States
Lincoln, Nebraska 68516, United States
Brooklyn, New York 11201, United States
Belmont, North Carolina 28012, United States
Charlotte, North Carolina 28204, United States
Charlotte, North Carolina 28207, United States
Charlotte, North Carolina 28211, United States
Oklahoma City, Oklahoma 73104, United States
London, Ontario N6A 4V2, Canada
Ottawa, Ontario K1H 1A2, Canada
Allentown, Pennsylvania 18103, United States
Bethlehem, Pennsylvania 18015, United States
Duncansville, Pennsylvania 16635, United States
Wexford, Pennsylvania 15090, United States
Wyomissing, Pennsylvania 19610, United States
Pointe-claire, Quebec H9R 3J1, Canada
Memphis, Tennessee 38104, United States
Dallas, Texas 75246, United States
Fort Worth, Texas 76107, United States
Houston, Texas 77034, United States
Houston, Texas 77459, United States
San Antonio, Texas 78232, United States
Tacoma, Washington 98405, United States