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Tadalafil and Acetazolamide Versus Acetazolamide in Acute Mountain Sickness Prevention

Information source: Sheba Medical Center
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Pulmonary Edema; Cerebral Edema

Intervention: Tadalafil and acetazolamide (Drug); Acetazolamide (Drug)

Phase: N/A

Status: Completed

Sponsored by: Sheba Medical Center


To evaluate the additive value of tadalafil given together with Diamox (acetazolamide) in preventing acute mountain sickness in travelers to high altitude areas.

Clinical Details

Official title: Tadalafil and Acetazolamide Versus Acetazolamide in Acute Mountain Sickness Prevention

Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Prevention

Primary outcome: Results will be evaluated by using the Lake Louise AMS scoring system

Detailed description: A randomized controlled study comparing: Tadalafil [20mg x1/day] and acetazolamide [125mg x2 day], versus Acetazolamide [125mg x2 day] alone, in trekkers to altitude > 3,000 m.


Minimum age: 18 Years. Maximum age: N/A. Gender(s): Both.


Inclusion Criteria:

- Participant in trekking to high altitude

- Agreement to sign the informed consent.

Exclusion Criteria:

- No agreement to sign informed consent.

Locations and Contacts

Tel Hashomer, Israel

Center of Geographic Medicine, Tel Hashomer, Israel

Sheba Medical Ctr., Tel hashomer, Israel

Additional Information

Starting date: January 2006
Last updated: September 7, 2012

Page last updated: August 23, 2015

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