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Tadalafil and Acetazolamide Versus Acetazolamide in Acute Mountain Sickness Prevention

Information source: Sheba Medical Center
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Pulmonary Edema; Cerebral Edema

Intervention: Tadalafil and acetazolamide (Drug); Acetazolamide (Drug)

Phase: N/A

Status: Completed

Sponsored by: Sheba Medical Center

Summary

To evaluate the additive value of tadalafil given together with Diamox (acetazolamide) in preventing acute mountain sickness in travelers to high altitude areas.

Clinical Details

Official title: Tadalafil and Acetazolamide Versus Acetazolamide in Acute Mountain Sickness Prevention

Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Prevention

Primary outcome: Results will be evaluated by using the Lake Louise AMS scoring system

Detailed description: A randomized controlled study comparing: Tadalafil [20mg x1/day] and acetazolamide [125mg x2 day], versus Acetazolamide [125mg x2 day] alone, in trekkers to altitude > 3,000 m.

Eligibility

Minimum age: 18 Years. Maximum age: N/A. Gender(s): Both.

Criteria:

Inclusion Criteria:

- Participant in trekking to high altitude

- Agreement to sign the informed consent.

Exclusion Criteria:

- No agreement to sign informed consent.

Locations and Contacts

Tel Hashomer, Israel

Center of Geographic Medicine, Tel Hashomer, Israel

Sheba Medical Ctr., Tel hashomer, Israel

Additional Information

Starting date: January 2006
Last updated: September 7, 2012

Page last updated: August 23, 2015

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