Vasodilation Effect of Inhalational Anesthetics

Condition(s) targeted: General Anesthesia

Intervention: Halothane (Drug); Isoflurane (Drug); Sevoflurane (Drug); Desflurane (Drug); Enflurane (Drug)

Phase: N/A

Status: Completed

Sponsored by: Nanjing Medical University

Official(s) and/or principal investigator(s):
XiaoFeng Shen, MD, Study Director, Affiliation: Nanjing Medical University

Previous studies on animals suggest that inhalational anesthetics can reduce vascular tension in vitro resulting in vasodilation and decrease in blood pressure. This role for inhalational anesthetics has essential clinical implications such as the condition of sepsis or septic shock or other shock-associated states during which the blood vessel constricts strongly and leads to circulation dysfunction. The vasodilation property of these anesthetics including halothane, isoflurane, sevoflurane, desflurane and enflurane enables them to be better options than other general anesthetics in many clinical conditions needing the vasculature to be dilated. The investigators hypothesized that these inhalational anesthetics can evoke vasodilation measured with ultrasonography during general anesthesia in vivo as the in vitro studies displayed.

Official title: Vasodilation Effect of Inhalational Anesthetics Including Halothane, Isoflurane, Sevoflurane, Desflurane and Enflurane

Study design: Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Primary outcome: Ultrasonography of blood vessels including radial artery, brachial artery, femoral artery, popliteal artery

Secondary outcome:

Blood flow volume during anesthesia of the vasculature

Blood pressure including systolic, diastolic and mean artery blood pressures

The time interval of between the initiation of the inhalational anesthetics delivered to the beginning of decreasing of blood pressure

The total dose of phenylephrine required to maintain baseline arterial blood pressure

Regression and correlation analyses between different doses of the anesthetics and the extent of vasodilation

Minimum age: 19 Years. Maximum age: 45 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- Must be undergoing general anesthesia

- Age between 19-45 years

Exclusion Criteria:

- With hypertension

- Existing organic dysfunction

- Allergic to inhalant anesthetics

- Alcohol addictive or narcotic dependent patients

- A history of the use of centrally-acting drugs of any sort, chronic pain and

psychiatric diseases records

Nanjing Maternal and Child Health Care Hospital, Nanjing, Jiangsu 210004, China

Starting date: December 2008
Last updated: December 22, 2009