The purpose of this study is to examine the colchicine concentration before and after the
administration of rifampicin.
Minimum age: 19 Years.
Maximum age: 80 Years.
Gender(s): Both.
Inclusion Criteria:
- from 18yrs to 80yrs , man and women
- the patient who are taking rifampicine over 2weeks
- the patient sign on the concent form
Exclusion Criteria:
- the patient have experience to take medication that have an effect on renal function
- the patient have hypersensitivity to colchicine
- At least, the average level of two separate blood pressure ( 2min interval ) shows
that SBP <= 100 mmHg or >=160 mmHg and DBP <=60 mmHg >=100 mmHg, or Heart rate < 40
beats/min or > 90 beats/min
- uncontrolled hypertension
- serum albumin < 3. 5, > 5 g/dL
- acute hepatitis or the level of AST or ALT is over 2times of normal range or the
level of bilirubin is over 2. 0 mg/dL
- the patient who have gastro-intestinal disease ( ex, crohn's disease, acute or
chronic pancreatitis, ulcer )or who have the surgical history of gastrointestine.
- the patient who should take azathioprine, mercaptopurine, cyclophosphamide, Losartan,
benzbromarone,fenofibrate,furosemide ,probenecid
- the patient who had taken part in the other study within 3months
- the patient who had gotten blood transfusion
- pregnant, breast feeding