Gut Hormones After Oral Versus Intravenous Amino Acids
Information source: Lund University
Information obtained from ClinicalTrials.gov on December 08, 2011
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Normal Non-fluency
Intervention: Oral amino acid mixture (Other); Intravenous amino acid administration (Other)
Phase: N/A
Status: Recruiting
Sponsored by: Lund University Official(s) and/or principal investigator(s):
Bo Ahrén, PhD, Principal Investigator, Affiliation: Lund University
Overall contact:
Bo Ahrén, PhD, Phone: 46462220758, Email: Bo.Ahren@med.lu.se
Summary
The study hypothesis is that gut hormones are released after oral but not intravenous amino
acids which result in stimulation of insulin secretion.
Clinical Details
Official title: Release of Gut Hormones After Oral Versus Intravenous Amino Acids
Study design: Allocation: Non-Randomized, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Basic Science
Primary outcome: Gut hormone secretion
Secondary outcome: Insulin secretion
Detailed description:
Amino acid mixture is given orally or intravenously to match total concentrations of amino
acids in healthy subjects. Samples are taken regularly for 300 min after administrations.
Plasma levels of the gut hormones glucose-dependent insulinotropic polypeptide (GIP) and
glucagon-like peptide-1 (GLP-1)and determined and related to plasma levels of insulin and
glucagon.
Eligibility
Minimum age: 20 Years.
Maximum age: 30 Years.
Gender(s): Male.
Criteria:
Inclusion Criteria:
- Healthy subjects
Exclusion Criteria:
- Diabetes
- Liver disease
- Kidney disease
- Thyroid disease
Locations and Contacts
Bo Ahrén, PhD, Phone: 46462220758, Email: Bo.Ahren@med.lu.se
Department of Clinical Sciences Lund, Lund University, Lund 221 84, Sweden; Recruiting
Bo Ahrén, PhD, Phone: 46462220758, Email: Bo.Ahren@med.lu.se
Bo Ahrén, PhD, Principal Investigator
Additional Information
Starting date: May 2011
Last updated: June 3, 2011
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