Gut Hormones After Oral Versus Intravenous Amino Acids
Information source: Lund University
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Normal Non-fluency
Intervention: Oral amino acid mixture (Other); Intravenous amino acid administration (Other)
Sponsored by: Lund University
Official(s) and/or principal investigator(s):
Bo Ahrén, PhD, Principal Investigator, Affiliation: Lund University
The study hypothesis is that gut hormones are released after oral but not intravenous amino
acids which result in stimulation of insulin secretion.
Official title: Release of Gut Hormones After Oral Versus Intravenous Amino Acids
Study design: Allocation: Non-Randomized, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Basic Science
Primary outcome: Gut hormone secretion
Secondary outcome: Insulin secretion
Amino acid mixture is given orally or intravenously to match total concentrations of amino
acids in healthy subjects. Samples are taken regularly for 300 min after administrations.
Plasma levels of the gut hormones glucose-dependent insulinotropic polypeptide (GIP) and
glucagon-like peptide-1 (GLP-1)and determined and related to plasma levels of insulin and
Minimum age: 20 Years.
Maximum age: 30 Years.
- Healthy subjects
- Liver disease
- Kidney disease
- Thyroid disease
Locations and Contacts
Department of Clinical Sciences Lund, Lund University, Lund 221 84, Sweden
Starting date: May 2011
Last updated: October 9, 2012