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Evaluation of Therapeutic Effect of 0.5 mg Colchicine and 5 mg Prednisolone on Oral Aphthae

Information source: Mashhad University of Medical Sciences
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Oral Aphthae

Intervention: Prednisolone (Drug); Colchicine (Drug)

Phase: Phase 2

Status: Active, not recruiting

Sponsored by: Mashhad University of Medical Sciences


The purpose of this study is to determine whether low doses of prednisolone, or colchicine are effective in the treatment of oral aphthae.

Clinical Details

Official title: Evaluation of Therapeutic Effect of 0.5 mg Colchicine and 5 mg Prednisolone on Oral Aphthae

Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Investigator), Primary Purpose: Treatment

Primary outcome: frequency of ulcers

Detailed description: Treatment of recurrent aphthous stomatitis (RAS) remains, to date, empirical and non-specific. The main goals of therapy are to minimize pain and functional disabilities as well as decrease inflammatory reactions and frequency of recurrences.


Minimum age: 15 Years. Maximum age: 60 Years. Gender(s): Both.


Inclusion Criteria:

- Confirmation of clinical diagnosis of aphthae

- Having the experience of oral aphthae at least once in a month

- Two weeks wash out periods after the last treatment

Exclusion Criteria:

- History of any systemic disease

- Using drugs which affect immune system

- Pregnancy and breast feeding

- Aphthous related syndromes

Locations and Contacts

Mashhad Dental school, Mashhad, Khorasan Razavi 91735, Iran, Islamic Republic of
Additional Information

Mashhad Dental Research Center

Starting date: May 2007
Last updated: July 28, 2008

Page last updated: August 23, 2015

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