Evaluation of Therapeutic Effect of 0.5 mg Colchicine and 5 mg Prednisolone on Oral Aphthae
Information source: Mashhad University of Medical Sciences
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Oral Aphthae
Intervention: Prednisolone (Drug); Colchicine (Drug)
Phase: Phase 2
Status: Active, not recruiting
Sponsored by: Mashhad University of Medical Sciences
Summary
The purpose of this study is to determine whether low doses of prednisolone, or colchicine
are effective in the treatment of oral aphthae.
Clinical Details
Official title: Evaluation of Therapeutic Effect of 0.5 mg Colchicine and 5 mg Prednisolone on Oral Aphthae
Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Investigator), Primary Purpose: Treatment
Primary outcome: frequency of ulcers
Detailed description:
Treatment of recurrent aphthous stomatitis (RAS) remains, to date, empirical and
non-specific. The main goals of therapy are to minimize pain and functional disabilities as
well as decrease inflammatory reactions and frequency of recurrences.
Eligibility
Minimum age: 15 Years.
Maximum age: 60 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- Confirmation of clinical diagnosis of aphthae
- Having the experience of oral aphthae at least once in a month
- Two weeks wash out periods after the last treatment
Exclusion Criteria:
- History of any systemic disease
- Using drugs which affect immune system
- Pregnancy and breast feeding
- Aphthous related syndromes
Locations and Contacts
Mashhad Dental school, Mashhad, Khorasan Razavi 91735, Iran, Islamic Republic of
Additional Information
Mashhad Dental Research Center
Starting date: May 2007
Last updated: July 28, 2008
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