Platelet Inhibition by Aspirin, Acetaminophen and NSAID
Information source: Kantonsspital Graubünden
Information obtained from ClinicalTrials.gov on June 20, 2008
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Hemostasis
Intervention: Acetylsalicylic acid, acetaminophen, diclofenac, naproxen, placebo (Drug)
Phase: N/A
Status: Completed
Sponsored by: Kantonsspital Graubünden Official(s) and/or principal investigator(s):
Walter H Reinhart, MD Professor, Principal Investigator, Affiliation: Department of Internal Medicine, Kantonsspital Graubunden CH7000 Chur Switzerland
Summary
Nonsteroidal antiinflammatory drugs such as diclofenac or naproxen may interfere with the
inhibition of platelet aggregation by aspirin, because they all interact with the platelet
cyclooxygenase. This may be of great clinical importance because of an increased
cardiovascular event rate (myocardial infarction, stroke). The present randomized, controlled
study analyses in vitro platelet aggregation under a combined treatment of healthy volunteers
with aspirin and either acetaminophen, diclofenac, naproxen, or placebo.
Clinical Details
Study design: Treatment, Randomized, Single Blind (Subject), Placebo Control, Parallel Assignment, Efficacy Study
Primary outcome: platelet aggregation
Detailed description:
An in vivo study on healthy volunteers with combinations of well established drugs
Eligibility
Minimum age: N/A.
Maximum age: N/A.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- Healthy volunteers
Exclusion Criteria:
- Administration of drugs affecting platelets
- History of bleeding
- Gastrointestinal disorders
- Hypersensitivity to aspirin and/or NSAID
- Pregnancy and breast feeding
Locations and Contacts
Kantonsspital Graubünden, Department of Internal Medicine, Chur CH 7000, Switzerland
Additional Information
Starting date: August 2006
Ending date: August 2007
Last updated: September 27, 2007
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