Safety and Effectiveness of tPA in Intra-Abdominal Abscesses
Information source: University Health Network, Toronto
Information obtained from ClinicalTrials.gov on October 19, 2009
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Abscess
Intervention: tissue plasminogen activator (Drug)
Phase: Phase 2/Phase 3
Status: Recruiting
Sponsored by: University Health Network, Toronto Official(s) and/or principal investigator(s):
Dheeraj Rajan, MD, Principal Investigator, Affiliation: University Health Network - University of Toronto
Murray Asch, MD, Principal Investigator, Affiliation: Lakeridge Health Science Center
Overall contact:
Dheeraj Rajan, MD, Phone: 416-340-4911, Email: dheeraj.rajan@uhn.on.ca
Summary
To determine if instillation of tissue plasminogen activator into a percutaneously drained
intraabdominal abscess cavity results in faster resolution of the abscess compared to normal
standard of care.
Clinical Details
Official title: Safety and Effectiveness of Local Instillation of tPA in the Management of Complex Intra-Abdominal Fluid Collections: a Randomized, Double Blinded Controlled Clinical Trial
Study design: Treatment, Randomized, Double Blind (Subject, Caregiver), Active Control, Parallel Assignment, Safety/Efficacy Study
Primary outcome: time to eatingtime to discharge radiological evidence of resolution
Secondary outcome: cost comparison
Eligibility
Minimum age: 18 Years.
Maximum age: N/A.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- Intrabdominal abscess
Exclusion Criteria:
- Hypersensitivity to tPA
- Recent stroke
- Uncontrolled htn
- Recent major hemorrhage
- Pregnancy
Locations and Contacts
Dheeraj Rajan, MD, Phone: 416-340-4911, Email: dheeraj.rajan@uhn.on.ca
University Health Network, Toronto, Ontario M5G2N2, Canada; Recruiting
Dheeraj Rajan, MD, Phone: 416-340-4911, Email: dheeraj.rajan@uhn.on.ca
Additional Information
Starting date: July 2005
Last updated: February 12, 2009
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