Succinylcholine Versus Rocuronium for Emergency Intubation in Intensive Care
Information source: University Hospital, Basel, Switzerland
ClinicalTrials.gov processed this data on August 23, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Intubation
Intervention: Succinylcholine (Drug); Rocuronium (Drug)
Phase: Phase 4
Status: Completed
Sponsored by: University Hospital, Basel, Switzerland Official(s) and/or principal investigator(s): Martin Siegemund, MD, Principal Investigator, Affiliation: Department of Surgical Intensive Care, University of Basel Stephan C Marsch, MD, DPhil, Principal Investigator, Affiliation: Department of Medical Intensive Care, University of Basel
Summary
Emergency intubation of patients in intensive care is a high-risk endeavour. For many
decades, succinylcholine has been the neuromuscular blocking agent of choice. However,
succinylcholine may have life-threatening side effects and is contraindicated in a variety
of diseases relevant in intensive care. The nondepolarizing agent rocuronium has been
propagated as alternative for succinylcholine. Though a recent meta-analysis found no
difference in intubating conditions between succinylcholine and rocuronium in elective
cases, there are no data in emergent cases in intensive care. The aim of the present study
is to compare succinylcholine and rocuronium with regard to 1) quality of intubating
conditions, 2) length of the intubating sequence, 3) failed intubating attempts, 4)
hemodynamic sequelae of intubation, and 5) desaturations.
Clinical Details
Official title: Phase 4 Study of Succinylcholine Versus Rocuronium as Neuromuscular Blocking Agent for Emergency Intubation in Intensive Care
Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Subject), Primary Purpose: Treatment
Primary outcome: Number of Participants Exhibiting Desaturation >5%
Secondary outcome: Haemodynamic Sequelae of IntubationTime to Completion of Intubation Quality of Intubation Conditions Using a Validated Score: Viby-Mogensen et al. Good Clinical Research Practice (GCRP) in Pharmacodynamic Studies of Neuromuscular Blocking Agents. Acta Anaesthesiol Scand 1996;40:59-74. Number of Participants With an Failed First Intubation Attempts
Detailed description:
Objective: to compare succinylcholine and rocuronium with regard to 1) quality of intubating
conditions, 2) length of the intubating sequence, 3) failed intubating attempts, 4)
hemodynamic sequelae of intubation, and 5) desaturations.
Design: prospective, randomized, single-blind study. Setting: Intensive care units of an
University Hospital. Patients: adult patients in intensive care requiring emergency
intubation. Randomization: 1: 1 randomization to either succinylcholine (1mg/kg) or
rocuronium (0. 6 mg/kg).
Data: 1) assessment of the quality of intubating conditions by means of a score, 2) length
of the intubating sequence defined as time between injection of neuromuscular blocking agent
and first end-tidal CO2 on the monitor, 3) number of failed intubating attempts, 4)
hemodynamic sequelae of intubation, defined as events requiring injection of vasoactive
drugs, and 5) desaturations, defined as saturation below 90% and/or any decrease in
saturation of 5% or more.
Eligibility
Minimum age: 18 Years.
Maximum age: N/A.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- indication for emergency intubation in intensive care
- availability of qualified study physician
Exclusion Criteria:
- contraindication against succinylcholine or rocuronium
- indication for awake fibreoptic intubation
Locations and Contacts
Department of Medical Intensive Care; University of Basel, Basel, BS 4031, Switzerland
Additional Information
Related publications: Sluga M, Ummenhofer W, Studer W, Siegemund M, Marsch SC. Rocuronium versus succinylcholine for rapid sequence induction of anesthesia and endotracheal intubation: a prospective, randomized trial in emergent cases. Anesth Analg. 2005 Nov;101(5):1356-61.
Starting date: August 2006
Last updated: November 10, 2011
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