A Study of Disease Progression and Anti-HIV Treatments

Condition(s) targeted: HIV Infections

Intervention: Lamivudine (Drug)

Phase: Phase 2

Status: Completed

Sponsored by: National Institute of Allergy and Infectious Diseases (NIAID)

To determine the influence of virus load, CD4 count, biologic phenotype, and presence of symptomatic disease on the response of HIV-infected patients to a new therapeutic regimen. PER AMENDMENT 8/27/96: To extend the availability of currently assigned ACTG 303 treatment for 6 months.

Official title: Influence of Risk Status for Disease Progression on the Response to Antiretroviral Interventions: A Follow-Up Study to ACTG 175

Study design: Treatment, Randomized, Placebo Control, Parallel Assignment, Efficacy Study

Minimum age: 12 Years. Maximum age: N/A. Gender(s): Both.

Criteria:

Inclusion Criteria

Patients must have:

- Prior participation on protocol ACTG 175.

PER AMENDMENT 8/27/96:

- Patients must be on study/on treatment at the time the protocol study treatment is

extended.

Univ of Puerto Rico, San Juan 009365067, Puerto Rico

Univ of Alabama at Birmingham, Birmingham, Alabama 35294, United States

Stanford at Kaiser / Kaiser Permanente Med Ctr, San Francisco, California 94115, United States

San Francisco Gen Hosp, San Francisco, California 941102859, United States

San Francisco AIDS Clinic / San Francisco Gen Hosp, San Francisco, California 941102859, United States

Summitt Med Ctr / San Francisco Gen Hosp, Oakland, California 94609, United States

UCLA CARE Ctr, Los Angeles, California 90095, United States

Univ of Southern California / LA County USC Med Ctr, Los Angeles, California 900331079, United States

Children's Hosp of Los Angeles, Los Angeles, California 90027, United States

Harbor UCLA Med Ctr, Torrance, California 90502, United States

San Mateo AIDS Program / Stanford Univ, Stanford, California 943055107, United States

Santa Clara Valley Med Ctr / AIDS Community Rsch Consortium, San Jose, California 951282699, United States

Mountain States Reg Hemo Ctr / Univ of Colorado, Denver, Colorado 80262, United States

Univ of Colorado Health Sciences Ctr, Denver, Colorado 80262, United States

Georgetown Univ Med Ctr, Washington, District of Columbia 20007, United States

George Washington Univ / Hershey Med Ctr, Washington, District of Columbia 20037, United States

Georgetown Univ Hosp, Washington, District of Columbia 20037, United States

Univ of Miami School of Medicine, Miami, Florida 331361013, United States

Emory Hemo Comp Evaluation Clinic / East TN Comp Hemo Ctr, Atlanta, Georgia 303652225, United States

Children's Mem Hosp Family Cln / Northwestern Univ Med Schl, Chicago, Illinois 60611, United States

Northwestern Univ Med School, Chicago, Illinois 60611, United States

Rush Presbyterian - Saint Luke's Med Ctr, Chicago, Illinois 60612, United States

Cook County Hosp, Chicago, Illinois 60612, United States

Methodist Hosp of Indiana / Life Care Clinic, Indianapolis, Indiana 46202, United States

Great Plains - Hemophilia / Univ of Iowa Hosp & Clinic, Iowa City, Iowa 52242, United States

Johns Hopkins Hosp, Baltimore, Maryland 21287, United States

Harvard (Massachusetts Gen Hosp), Boston, Massachusetts 02114, United States

Beth Israel Deaconess Med Ctr, Boston, Massachusetts 02215, United States

Boston Med Ctr, Boston, Massachusetts 02118, United States

Michigan State Univ Hemophilia Comprehensive Care Clinic, Lansing, Michigan 48912, United States

Univ of Minnesota, Minneapolis, Minnesota 55455, United States

St Paul Ramsey Med Ctr, St. Paul, Minnesota 55101, United States

Univ of Nebraska Med Ctr, Omaha, Nebraska 681985130, United States

Dartmouth - Hitchcock Med Ctr / Med Ctr Cntrl Massachusetts, Lebanon, New Hampshire 03756, United States

Robert Wood Johnson Med School / Hershey Med Ctr, New Brunswick, New Jersey 08903, United States

SUNY / State Univ of New York, Syracuse, New York 13210, United States

Univ of Rochester Medical Center, Rochester, New York 14642, United States

Bellevue Hosp / New York Univ Med Ctr, New York, New York 10016, United States

Mount Sinai Med Ctr, New York, New York 10029, United States

Jack Weiler Hosp / Bronx Municipal Hosp, Bronx, New York 10465, United States

Cornell Univ Med Ctr, New York, New York 10021, United States

Bronx Municipal Hosp Ctr/Jacobi Med Ctr, Bronx, New York 10461, United States

Montefiore Med Ctr / Bronx Municipal Hosp, Bronx, New York 10467, United States

SUNY / Erie County Med Ctr at Buffalo, Buffalo, New York 14215, United States

Mount Sinai Med Ctr / Hemophilia Treatment Ctr, New York, New York 10029, United States

Beth Israel Med Ctr, New York, New York 10003, United States

Carolinas Med Ctr, Charlotte, North Carolina 28203, United States

Univ of North Carolina, Chapel Hill, North Carolina 275997215, United States

Moses H Cone Memorial Hosp, Greensboro, North Carolina 27401, United States

Case Western Reserve Univ, Cleveland, Ohio 44106, United States

Univ of Cincinnati, Cincinnati, Ohio 452670405, United States

Ohio State Univ Hosp Clinic, Columbus, Ohio 432101228, United States

Northwest Ohio Hemo Treatment Ctr / Great Lakes Hemo Fdn, Toledo, Ohio 43606, United States

Univ of Pennsylvania at Philadelphia, Philadelphia, Pennsylvania 19104, United States

Univ Texas Health Science Ctr / Univ Texas Med School, Houston, Texas 77030, United States

Univ of Texas Galveston, Galveston, Texas 775550435, United States

Univ of Washington, Seattle, Washington 981224304, United States

Great Lakes Hemophilia Foundation, Wauwatosa, Wisconsin 532130127, United States

Northern Wisconsin Hemophilia Ctr / Saint Vincent's Hosp, Green Bay, Wisconsin 54301, United States

Related publications:

Albrecht MA, Hughes MD, Liou SH, Katzenstein DA, Murphy R, Balfour HH, Para MF, Valdez H, Hammer SM. Effect of lamivudine in HIV-infected persons with prior exposure to zidovudine/didanosine or zidovudine/zalcitabine. AIDS Res Hum Retroviruses. 2000 Sep 20;16(14):1337-44.

Last updated: June 23, 2005