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A Study of Disease Progression and Anti-HIV Treatments

Information source: National Institute of Allergy and Infectious Diseases (NIAID)
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: HIV Infections

Intervention: Lamivudine (Drug)

Phase: Phase 2

Status: Completed

Sponsored by: National Institute of Allergy and Infectious Diseases (NIAID)

Summary

To determine the influence of virus load, CD4 count, biologic phenotype, and presence of symptomatic disease on the response of HIV-infected patients to a new therapeutic regimen. PER AMENDMENT 8/27/96: To extend the availability of currently assigned ACTG 303 treatment for 6 months.

Clinical Details

Official title: Influence of Risk Status for Disease Progression on the Response to Antiretroviral Interventions: A Follow-up Study to ACTG 175

Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Primary Purpose: Treatment

Eligibility

Minimum age: 12 Years. Maximum age: N/A. Gender(s): Both.

Criteria:

Inclusion Criteria Patients must have:

- Prior participation on protocol ACTG 175.

PER AMENDMENT 8/27/96:

- Patients must be on study/on treatment at the time the protocol study treatment is

extended.

Locations and Contacts

Puerto Rico-AIDS CRS, San Juan 00936, Puerto Rico

Mbeya Med. Research Program, Mbeya Referral Hosp. CRS, Mbeya, Tanzania

Alabama Therapeutics CRS, Birmingham, Alabama 35294, United States

UCLA CARE Center CRS, Los Angeles, California 90095, United States

USC CRS, Los Angeles, California 90033, United States

Stanford CRS, Palo Alto, California 94115, United States

Ucsd, Avrc Crs, San Diego, California, United States

Ucsf Aids Crs, San Francisco, California 94110, United States

Santa Clara Valley Med. Ctr., San Jose, California 95128, United States

San Mateo County AIDS Program, Stanford, California 94305, United States

Harbor-UCLA Med. Ctr. CRS, Torrance, California 90502, United States

University of Colorado Hospital CRS, Aurora, Colorado, United States

Univ. of Miami AIDS CRS, Miami, Florida 33136, United States

Emory Univ. Hemophilia Program Office, Atlanta, Georgia 30365, United States

Cook County Hosp. CORE Ctr., Chicago, Illinois 60612, United States

Northwestern University CRS, Chicago, Illinois 60611, United States

Rush Univ. Med. Ctr. ACTG CRS, Chicago, Illinois 60612, United States

Indiana Univ. School of Medicine, Infectious Disease Research Clinic, Indianapolis, Indiana, United States

Tulane Hemophilia Treatment Ctr., New Orleans, Louisiana, United States

Johns Hopkins Adult AIDS CRS, Baltimore, Maryland 21287, United States

Beth Israel Deaconess - East Campus A0102 CRS, Boston, Massachusetts, United States

Beth Israel Deaconess Med. Ctr., ACTG CRS, Boston, Massachusetts, United States

Bmc Actg Crs, Boston, Massachusetts 02118, United States

Massachusetts General Hospital ACTG CRS, Boston, Massachusetts 02114, United States

University of Minnesota, ACTU, Minneapolis, Minnesota 55455, United States

St. Louis ConnectCare, Infectious Diseases Clinic, St. Louis, Missouri, United States

Washington U CRS, St. Louis, Missouri, United States

Univ. of Nebraska Med. Ctr., Durham Outpatient Ctr., Omaha, Nebraska 68198, United States

SUNY - Buffalo, Erie County Medical Ctr., Buffalo, New York 14215, United States

Beth Israel Med. Ctr. (Mt. Sinai), New York, New York 10003, United States

Cornell University A2201, New York, New York 10021, United States

NY Univ. HIV/AIDS CRS, New York, New York 10016, United States

Univ. of Rochester ACTG CRS, Rochester, New York 14642, United States

Unc Aids Crs, Chapel Hill, North Carolina 27599, United States

Carolinas HealthCare System, Carolinas Med. Ctr., Charlotte, North Carolina 28203, United States

Regional Center for Infectious Disease, Wendover Medical Center CRS, Greensboro, North Carolina 27401, United States

Univ. of Cincinnati CRS, Cincinnati, Ohio 45267, United States

Case CRS, Cleveland, Ohio 44106, United States

The Ohio State Univ. AIDS CRS, Columbus, Ohio 43210, United States

Hosp. of the Univ. of Pennsylvania CRS, Philadelphia, Pennsylvania 19104, United States

University of Washington AIDS CRS, Seattle, Washington 98122, United States

Additional Information

Related publications:

Albrecht MA, Hughes MD, Liou SH, Katzenstein DA, Murphy R, Balfour HH, Para MF, Valdez H, Hammer SM; ACTG 303 Study Team. Effect of lamivudine in HIV-infected persons with prior exposure to zidovudine/didanosine or zidovudine/zalcitabine. AIDS Res Hum Retroviruses. 2000 Sep 20;16(14):1337-44.


Last updated: May 1, 2012

Page last updated: August 23, 2015

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